ENSG00000163737


Homo sapiens

Features
Gene ID: ENSG00000163737
  
Biological name :PF4
  
Synonyms : P02776 / PF4 / platelet factor 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.3
Gene start: 73981077
Gene end: 73982124
  
Corresponding Affymetrix probe sets: 206390_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296029
NCBI entrez gene - 5196     See in Manteia.
OMIM - 173460
RefSeq - NM_002619
RefSeq Peptide - NP_002610
swissprot - P02776
Ensembl - ENSG00000163737
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Pf4ENSMUSG00000029373Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PF4V1 / P10720 / platelet factor 4 variant 1ENSG0000010927286


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR027222  Platelet factor 4
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030168 platelet activation IDA
 biological_processGO:0030595 leukocyte chemotaxis IDA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IDA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042832 defense response to protozoan IDA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0045347 negative regulation of MHC class II biosynthetic process IDA
 biological_processGO:0045651 positive regulation of macrophage differentiation IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IDA
 biological_processGO:0045918 negative regulation of cytolysis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051873 killing by host of symbiont cells IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0020005 symbiont-containing vacuole membrane IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0097679 other organism cytoplasm IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0048248 CXCR3 chemokine receptor binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
G alpha (i) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163737 PF4 / P02776 / platelet factor 4  / complex






 

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