ENSMUSG00000029373


Mus musculus

Features
Gene ID: ENSMUSG00000029373
  
Biological name :Pf4
  
Synonyms : Pf4 / platelet factor 4 / Q9Z126
  
Possible biological names infered from orthology : P02776 / P10720 / PF4V1 / platelet factor 4 variant 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 90772435
Gene end: 90773383
  
Corresponding Affymetrix probe sets: 10523134 (MoGene1.0st)   1448995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143818
Ensembl peptide - ENSMUSP00000031320
NCBI entrez gene - 56744     See in Manteia.
MGI - MGI:1888711
RefSeq - NM_019932
RefSeq Peptide - NP_064316
swissprot - A0A0J9YTR7
swissprot - Q3TVN6
swissprot - Q9Z126
Ensembl - ENSMUSG00000029373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PF4ENSG00000163737Homo sapiens
 PF4V1ENSG00000109272Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR027222  Platelet factor 4
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation ISO
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process ISS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling ISS
 biological_processGO:0045347 negative regulation of MHC class II biosynthetic process ISO
 biological_processGO:0045651 positive regulation of macrophage differentiation ISO
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation ISS
 biological_processGO:0045918 negative regulation of cytolysis ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051873 killing by host of symbiont cells ISO
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0020005 symbiont-containing vacuole membrane ISO
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0097679 other organism cytoplasm ISO
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA
 molecular_functionGO:0048248 CXCR3 chemokine receptor binding ISS


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pf4tm1Mako/Pf4+
Genetic Background: B6.129X1-Pf4tm1Mako

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pf4tm1Mako/Pf4+
Genetic Background: B6.129X1-Pf4tm1Mako

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029373 Pf4 / Q9Z126 / platelet factor 4 / PF4V1* / P10720* / P02776* / platelet factor 4 variant 1*  / complex






 

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