ENSG00000163738


Homo sapiens

Features
Gene ID: ENSG00000163738
  
Biological name :MTHFD2L
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like / MTHFD2L / Q9H903
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 74114174
Gene end: 74303099
  
Corresponding Affymetrix probe sets: 1554841_at (Human Genome U133 Plus 2.0 Array)   1562644_at (Human Genome U133 Plus 2.0 Array)   220346_at (Human Genome U133 Plus 2.0 Array)   233083_at (Human Genome U133 Plus 2.0 Array)   238762_at (Human Genome U133 Plus 2.0 Array)   239562_at (Human Genome U133 Plus 2.0 Array)   242370_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391327
Ensembl peptide - ENSP00000387614
Ensembl peptide - ENSP00000405692
Ensembl peptide - ENSP00000409391
Ensembl peptide - ENSP00000321984
Ensembl peptide - ENSP00000352012
Ensembl peptide - ENSP00000379108
NCBI entrez gene - 441024     See in Manteia.
OMIM - 614047
RefSeq - XM_017008235
RefSeq - XM_017008227
RefSeq - XM_017008228
RefSeq - XM_017008229
RefSeq - XM_017008230
RefSeq - XM_017008231
RefSeq - XM_017008232
RefSeq - XM_017008234
RefSeq - NM_001004346
RefSeq - NM_001144978
RefSeq - XM_005265690
RefSeq - XM_017008218
RefSeq - XM_017008219
RefSeq - XM_017008220
RefSeq - XM_017008221
RefSeq - XM_017008222
RefSeq - XM_017008223
RefSeq - XM_017008224
RefSeq - XM_017008225
RefSeq - XM_017008226
RefSeq Peptide - NP_001138450
RefSeq Peptide - NP_001004346
swissprot - Q9H903
swissprot - A0A0C4DG60
swissprot - Q8IY64
swissprot - A0A024RDE0
swissprot - F8W7P9
Ensembl - ENSG00000163738
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd2lENSDARG00000054199Danio rerio
 MTHFD2LENSGALG00000010855Gallus gallus
 D3YZG8ENSMUSG00000029376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTHFD2 / P13995 / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseENSG0000006591164


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000105 histidine biosynthetic process IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009086 methionine biosynthetic process IEA
 biological_processGO:0009256 10-formyltetrahydrofolate metabolic process IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity TAS
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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