ENSG00000065911


Homo sapiens

Features
Gene ID: ENSG00000065911
  
Biological name :MTHFD2
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase / MTHFD2 / P13995
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.1
Gene start: 74198562
Gene end: 74217565
  
Corresponding Affymetrix probe sets: 201761_at (Human Genome U133 Plus 2.0 Array)   234976_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386536
Ensembl peptide - ENSP00000419550
Ensembl peptide - ENSP00000419067
Ensembl peptide - ENSP00000386542
Ensembl peptide - ENSP00000377617
NCBI entrez gene - 10797     See in Manteia.
OMIM - 604887
RefSeq - NM_006636
RefSeq - XM_006711924
RefSeq Peptide - NP_006627
swissprot - P13995
swissprot - F8WF89
swissprot - B8ZZU9
swissprot - F8WF06
swissprot - B9A062
Ensembl - ENSG00000065911
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd2ENSDARG00000098646Danio rerio
 MTHFD2ENSGALG00000034344Gallus gallus
 Mthfd2ENSMUSG00000005667Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H903 / MTHFD2L / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 likeENSG0000016373864


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IDA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity TAS
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity TAS
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042301 phosphate ion binding IMP


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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