ENSMUSG00000005667


Mus musculus

Features
Gene ID: ENSMUSG00000005667
  
Biological name :Mthfd2
  
Synonyms : Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase / Mthfd2 / P18155
  
Possible biological names infered from orthology : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase / P13995
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83305691
Gene end: 83325908
  
Corresponding Affymetrix probe sets: 10545672 (MoGene1.0st)   1419253_at (Mouse Genome 430 2.0 Array)   1419254_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145222
Ensembl peptide - ENSMUSP00000145266
Ensembl peptide - ENSMUSP00000005810
NCBI entrez gene - 17768     See in Manteia.
MGI - MGI:1338850
RefSeq - XM_006505697
RefSeq - XM_011241245
RefSeq - NM_008638
RefSeq Peptide - NP_032664
swissprot - P18155
swissprot - A0A0N4SVW2
swissprot - A0A0N4SVS2
Ensembl - ENSMUSG00000005667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd2ENSDARG00000098646Danio rerio
 MTHFD2ENSGALG00000034344Gallus gallus
 MTHFD2ENSG00000065911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
D3YZG8 / Mthfd2l / Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolas...ENSMUSG0000002937664


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity ISO
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042301 phosphate ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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