ENSDARG00000098646


Danio rerio

Features
Gene ID: ENSDARG00000098646
  
Biological name :mthfd2
  
Synonyms : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase / mthfd2
  
Possible biological names infered from orthology : Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase / P13995 / P18155
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 69716458
Gene end: 69732754
  
Corresponding Affymetrix probe sets: Dr.5222.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000132963
NCBI entrez gene - 100004977     See in Manteia.
RefSeq - NM_001002181
RefSeq Peptide - NP_001002181
swissprot - Q6GMK2
ZFIN ID - ZDB-GENE-040704-20
Ensembl - ENSDARG00000098646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MTHFD2ENSGALG00000034344Gallus gallus
 MTHFD2ENSG00000065911Homo sapiens
 Mthfd2ENSMUSG00000005667Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mthfd2l / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like / D3YZG8* / Q9H903* / Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 NAD-dependent...ENSDARG0000005419957


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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