ENSGALG00000034344


Gallus gallus

Features
Gene ID: ENSGALG00000034344
  
Biological name :MTHFD2
  
Synonyms : bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial / MTHFD2
  
Possible biological names infered from orthology : Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase / P13995 / P18155
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 2886809
Gene end: 2893328
  
Corresponding Affymetrix probe sets: Gga.2672.1.S1_at (Chicken Array)   Gga.2672.2.S1_s_at (Chicken Array)   GgaAffx.12282.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057027
NCBI entrez gene - 426126     See in Manteia.
RefSeq - NM_001031360
RefSeq Peptide - NP_001026531
swissprot - A0A1D5PVQ2
Ensembl - ENSGALG00000034344
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd2ENSDARG00000098646Danio rerio
 MTHFD2ENSG00000065911Homo sapiens
 Mthfd2ENSMUSG00000005667Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MTHFD2L / methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like / D3YZG8* / Q9H903* / Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 NAD-dependent...ENSGALG0000001085566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR016040  NAD(P)-binding domain
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0042301 phosphate ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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