ENSMUSG00000029376


Mus musculus

Features
Gene ID: ENSMUSG00000029376
  
Biological name :Mthfd2l
  
Synonyms : D3YZG8 / Mthfd2l / Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase
  
Possible biological names infered from orthology : methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like / Q9H903
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 90931117
Gene end: 91021368
  
Corresponding Affymetrix probe sets: 10523161 (MoGene1.0st)   1429599_a_at (Mouse Genome 430 2.0 Array)   1429600_at (Mouse Genome 430 2.0 Array)   1429601_x_at (Mouse Genome 430 2.0 Array)   1435488_at (Mouse Genome 430 2.0 Array)   1445743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071578
Ensembl peptide - ENSMUSP00000144302
NCBI entrez gene - 665563     See in Manteia.
MGI - MGI:1915871
RefSeq - NM_026788
RefSeq - XM_006535176
RefSeq - XM_006535177
RefSeq Peptide - NP_081064
swissprot - D3YZG8
swissprot - A0A0J9YUR4
Ensembl - ENSMUSG00000029376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfd2lENSDARG00000054199Danio rerio
 MTHFD2LENSGALG00000010855Gallus gallus
 Q9H903ENSG00000163738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mthfd2 / P18155 / Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydro...ENSMUSG0000000566766


Protein motifs (from Interpro)
Interpro ID Name
 IPR000672  Tetrahydrofolate dehydrogenase/cyclohydrolase
 IPR020630  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
 IPR020631  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
 IPR020867  Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000105 histidine biosynthetic process IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009086 methionine biosynthetic process IEA
 biological_processGO:0009256 10-formyltetrahydrofolate metabolic process IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004477 methenyltetrahydrofolate cyclohydrolase activity IBA
 molecular_functionGO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
 molecular_functionGO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Mogstm1.1(KOMP)Vlcg/Mogstm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mogstm1.1(KOMP)Vlcg/Bay

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Mogstm1.1(KOMP)Vlcg/Mogstm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mogstm1.1(KOMP)Vlcg/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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