ENSG00000163938


Homo sapiens

Features
Gene ID: ENSG00000163938
  
Biological name :GNL3
  
Synonyms : GNL3 / G protein nucleolar 3 / Q9BVP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.1
Gene start: 52681156
Gene end: 52694492
  
Corresponding Affymetrix probe sets: 217850_at (Human Genome U133 Plus 2.0 Array)   228395_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378278
Ensembl peptide - ENSP00000420345
Ensembl peptide - ENSP00000419895
Ensembl peptide - ENSP00000419734
Ensembl peptide - ENSP00000395772
NCBI entrez gene - 26354     See in Manteia.
OMIM - 608011
RefSeq - NM_014366
RefSeq - NM_206825
RefSeq - NM_206826
RefSeq Peptide - NP_996561
RefSeq Peptide - NP_996562
RefSeq Peptide - NP_055181
swissprot - Q9BVP2
swissprot - C9JYH9
swissprot - B4DMU5
swissprot - C9JZT7
Ensembl - ENSG00000163938
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnl3ENSDARG00000006219Danio rerio
 GNL3ENSGALG00000001613Gallus gallus
 Gnl3ENSMUSG00000042354Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNL3L / Q9NVN8 / G protein nucleolar 3 likeENSG0000013011930


Protein motifs (from Interpro)
Interpro ID Name
 IPR006073  GTP binding domain
 IPR014813  Guanine nucleotide-binding protein-like 3, N-terminal domain
 IPR023179  GTP-binding protein, orthogonal bundle domain superfamily
 IPR027368  tRNA modification GTPase MnmE domain 2
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030378  Circularly permuted (CP)-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0017145 stem cell division IDA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0032206 positive regulation of telomere maintenance IMP
 biological_processGO:0033235 positive regulation of protein sumoylation IMP
 biological_processGO:0042127 regulation of cell proliferation ISS
 biological_processGO:0042254 ribosome biogenesis IBA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IMP
 biological_processGO:1904816 positive regulation of protein localization to chromosome, telomeric region IMP
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISS
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165732 DDX21 / Q9NR30 / DExD-box helicase 21  / complex
 ENSG00000100029 PES1 / O00541 / pescadillo ribosomal biogenesis factor 1  / complex
 ENSG00000117395 Q99848 / EBNA1BP2 / EBNA1 binding protein 2  / complex






 

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