ENSMUSG00000042354


Mus musculus

Features
Gene ID: ENSMUSG00000042354
  
Biological name :Gnl3
  
Synonyms : Gnl3 / guanine nucleotide binding protein-like 3 (nucleolar) / Q8CI11
  
Possible biological names infered from orthology : G protein nucleolar 3 / Q9BVP2
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 31012433
Gene end: 31019152
  
Corresponding Affymetrix probe sets: 10418480 (MoGene1.0st)   1433656_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154745
Ensembl peptide - ENSMUSP00000047119
Ensembl peptide - ENSMUSP00000153981
Ensembl peptide - ENSMUSP00000154428
Ensembl peptide - ENSMUSP00000154477
NCBI entrez gene - 30877     See in Manteia.
MGI - MGI:1353651
RefSeq - NM_153547
RefSeq Peptide - NP_705775
swissprot - Q8CI11
Ensembl - ENSMUSG00000042354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnl3ENSDARG00000006219Danio rerio
 GNL3ENSGALG00000001613Gallus gallus
 GNL3ENSG00000163938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnl3l / Q6PGG6 / guanine nucleotide binding protein-like 3 (nucleolar)-like / Q9NVN8* / G protein nucleolar 3 like*ENSMUSG0000002526630


Protein motifs (from Interpro)
Interpro ID Name
 IPR006073  GTP binding domain
 IPR014813  Guanine nucleotide-binding protein-like 3, N-terminal domain
 IPR023179  GTP-binding protein, orthogonal bundle domain superfamily
 IPR027368  tRNA modification GTPase MnmE domain 2
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030378  Circularly permuted (CP)-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0017145 stem cell division IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042254 ribosome biogenesis IBA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904816 positive regulation of protein localization to chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * ICR

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3+
Genetic Background: Not Specified

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic Background: Not Specified

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic Background: Not Specified

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Porcntm1.1Jrt/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * ICR

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006102 reduced tegmentum "reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gnl3tm2.2Rylt/Gnl3tm2.2Rylt
Genetic Background: involves: 129 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst,Trp53tm1Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Gnl3Gt(W223E05)Wrst/Gnl3Gt(W223E05)Wrst
Genetic Background: Not Specified

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Gnl3tm2.1Rylt/Gnl3tm2.1Rylt,Trp53tm1Tyj/Trp53tm1Tyj,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6 * CBA

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0012203 abnormal neuronal stem cell morphology "any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
Show

Allelic Composition: Porcntm1.1Jrt/Porcn+
Genetic Background: B6.Cg-Porcntm1.1Jrt

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Amntm1Ehl/Amntm1Ehl
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020430 Pes1 / Q9EQ61 / Pescadillo homolog / O00541* / pescadillo ribosomal biogenesis factor 1*  / complex
 ENSMUSG00000028729 Q9D903 / Ebna1bp2 / Probable rRNA-processing protein EBP2 / Q99848* / EBNA1 binding protein 2*  / complex
 ENSMUSG00000020075 Ddx21 / Q9JIK5 / Nucleolar RNA helicase 2 / Q9NR30* / DExD-box helicase 21*  / complex






 

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