ENSMUSG00000020430


Mus musculus

Features
Gene ID: ENSMUSG00000020430
  
Biological name :Pes1
  
Synonyms : Pes1 / Pescadillo homolog / Q9EQ61
  
Possible biological names infered from orthology : O00541 / pescadillo ribosomal biogenesis factor 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 3963975
Gene end: 3980004
  
Corresponding Affymetrix probe sets: 10373814 (MoGene1.0st)   1416172_at (Mouse Genome 430 2.0 Array)   1416173_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020705
Ensembl peptide - ENSMUSP00000105612
NCBI entrez gene - 64934     See in Manteia.
MGI - MGI:1890613
RefSeq - XM_017314702
RefSeq - NM_022889
RefSeq Peptide - NP_075027
swissprot - Q5SQ20
swissprot - Q9EQ61
Ensembl - ENSMUSG00000020430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pesENSDARG00000018902Danio rerio
 PES1ENSGALG00000007778Gallus gallus
 PES1ENSG00000100029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR010613  Pescadillo
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0006364 rRNA processing ISO
 biological_processGO:0007000 nucleolus organization IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0033365 protein localization to organelle IMP
 biological_processGO:0042254 ribosome biogenesis IMP
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030687 preribosome, large subunit precursor IEA
 cellular_componentGO:0070545 PeBoW complex IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Itga2btm1Tlr/Itga2btm1Tlr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itga2btm1Tlr/Itga2btm1Tlr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Itga2btm1Tlr/Itga2btm1Tlr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028729 Q9D903 / Ebna1bp2 / Probable rRNA-processing protein EBP2 / Q99848* / EBNA1 binding protein 2*  / complex
 ENSMUSG00000020075 Ddx21 / Q9JIK5 / Nucleolar RNA helicase 2 / Q9NR30* / DExD-box helicase 21*  / complex
 ENSMUSG00000042354 Gnl3 / Q8CI11 / guanine nucleotide binding protein-like 3 (nucleolar) / Q9BVP2* / G protein nucleolar 3*  / complex
 ENSMUSG00000022557 Bop1 / P97452 / Ribosome biosis protein BOP1 / Q14137* / block of proliferation 1*  / complex
 ENSMUSG00000026019 Wdr12 / Q9JJA4 / WD repeat domain 12 / Q9GZL7*  / complex






 

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