ENSMUSG00000026019


Mus musculus

Features
Gene ID: ENSMUSG00000026019
  
Biological name :Wdr12
  
Synonyms : Q9JJA4 / Wdr12 / WD repeat domain 12
  
Possible biological names infered from orthology : Q9GZL7
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 60069785
Gene end: 60098645
  
Corresponding Affymetrix probe sets: 10355037 (MoGene1.0st)   10550098 (MoGene1.0st)   1417270_at (Mouse Genome 430 2.0 Array)   1448646_at (Mouse Genome 430 2.0 Array)   1459762_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113148
Ensembl peptide - ENSMUSP00000117391
Ensembl peptide - ENSMUSP00000117747
Ensembl peptide - ENSMUSP00000027173
Ensembl peptide - ENSMUSP00000113494
NCBI entrez gene - 57750     See in Manteia.
MGI - MGI:1927241
RefSeq - XM_017321861
RefSeq - NM_001199060
RefSeq - NM_001199061
RefSeq - NM_021312
RefSeq - XM_011238563
RefSeq Peptide - NP_001185990
RefSeq Peptide - NP_067287
RefSeq Peptide - NP_001185989
swissprot - Q4V9X1
swissprot - Q9JJA4
swissprot - D3Z369
Ensembl - ENSMUSG00000026019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr12ENSDARG00000003287Danio rerio
 WDR12ENSGALG00000008470Gallus gallus
 WDR12ENSG00000138442Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR012972  NLE
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR028599  WD repeat WDR12/Ytm1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000460 maturation of 5.8S rRNA IBA
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
 biological_processGO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
 biological_processGO:0000470 maturation of LSU-rRNA IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0007219 Notch signaling pathway IPI
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0030687 preribosome, large subunit precursor ISO
 cellular_componentGO:0070545 PeBoW complex IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022557 Bop1 / P97452 / Ribosome biosis protein BOP1 / Q14137* / block of proliferation 1*  / complex
 ENSMUSG00000020430 Pes1 / Q9EQ61 / Pescadillo homolog / O00541* / pescadillo ribosomal biogenesis factor 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr