ENSG00000138442


Homo sapiens

Features
Gene ID: ENSG00000138442
  
Biological name :WDR12
  
Synonyms : Q9GZL7 / WDR12 / WD repeat domain 12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q33.2
Gene start: 202874782
Gene end: 203014798
  
Corresponding Affymetrix probe sets: 218512_at (Human Genome U133 Plus 2.0 Array)   238826_x_at (Human Genome U133 Plus 2.0 Array)   241687_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261015
NCBI entrez gene - 55759     See in Manteia.
OMIM - 616620
RefSeq - XM_011511469
RefSeq - NM_018256
RefSeq Peptide - NP_060726
swissprot - Q53T99
swissprot - Q9GZL7
Ensembl - ENSG00000138442
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr12ENSDARG00000003287Danio rerio
 WDR12ENSGALG00000008470Gallus gallus
 Wdr12ENSMUSG00000026019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR012972  NLE
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR028599  WD repeat WDR12/Ytm1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0030687 preribosome, large subunit precursor IEA
 cellular_componentGO:0070545 PeBoW complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000261236 BOP1 / Q14137 / block of proliferation 1  / complex
 ENSG00000100029 PES1 / O00541 / pescadillo ribosomal biogenesis factor 1  / complex






 

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