ENSG00000261236


Homo sapiens

Features
Gene ID: ENSG00000261236
  
Biological name :BOP1
  
Synonyms : block of proliferation 1 / BOP1 / Q14137
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 144262102
Gene end: 144291370
  
Corresponding Affymetrix probe sets: 212563_at (Human Genome U133 Plus 2.0 Array)   216397_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455106
Ensembl peptide - ENSP00000456082
NCBI entrez gene - 23246     See in Manteia.
OMIM - 610596
RefSeq - NM_015201
RefSeq Peptide - NP_056016
swissprot - A0A075B729
swissprot - Q14137
Ensembl - ENSG00000261236
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bop1ENSDARG00000063627Danio rerio
 Bop1ENSMUSG00000022557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR012953  BOP1, N-terminal domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR028598  WD repeat BOP1/Erb1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IMP
 biological_processGO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0030687 preribosome, large subunit precursor IBA
 cellular_componentGO:0070545 PeBoW complex IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138442 WDR12 / Q9GZL7 / WD repeat domain 12  / complex
 ENSG00000100029 PES1 / O00541 / pescadillo ribosomal biogenesis factor 1  / complex






 

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