ENSMUSG00000020075


Mus musculus

Features
Gene ID: ENSMUSG00000020075
  
Biological name :Ddx21
  
Synonyms : Ddx21 / Nucleolar RNA helicase 2 / Q9JIK5
  
Possible biological names infered from orthology : DExD-box helicase 21 / Q9NR30
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62580251
Gene end: 62602281
  
Corresponding Affymetrix probe sets: 10369630 (MoGene1.0st)   1448270_at (Mouse Genome 430 2.0 Array)   1448271_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042691
NCBI entrez gene - 56200     See in Manteia.
MGI - MGI:1860494
RefSeq - NM_019553
RefSeq Peptide - NP_062426
swissprot - Q9JIK5
Ensembl - ENSMUSG00000020075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx21ENSDARG00000063626Danio rerio
 DDX21ENSGALG00000004144Gallus gallus
 DDX21ENSG00000165732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx50 / Q99MJ9 / ATP-dependent RNA helicase DDX50 / Q9BQ39* / DExD-box helicase 50*ENSMUSG0000002007650


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR012562  GUCT
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISS
 molecular_functionGO:0003724 RNA helicase activity ISS
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0030515 snoRNA binding IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0097322 7SK snRNA binding IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bach2m2Anu/Bach2m2Anu
Genetic Background: C57BL/6NCrlAnu-Bach2m2Anu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020430 Pes1 / Q9EQ61 / Pescadillo homolog / O00541* / pescadillo ribosomal biogenesis factor 1*  / complex
 ENSMUSG00000028729 Q9D903 / Ebna1bp2 / Probable rRNA-processing protein EBP2 / Q99848* / EBNA1 binding protein 2*  / complex
 ENSMUSG00000042354 Gnl3 / Q8CI11 / guanine nucleotide binding protein-like 3 (nucleolar) / Q9BVP2* / G protein nucleolar 3*  / complex






 

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