ENSG00000165732


Homo sapiens

Features
Gene ID: ENSG00000165732
  
Biological name :DDX21
  
Synonyms : DDX21 / DExD-box helicase 21 / Q9NR30
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 68956128
Gene end: 68985073
  
Corresponding Affymetrix probe sets: 208152_s_at (Human Genome U133 Plus 2.0 Array)   224654_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000346120
Ensembl peptide - ENSP00000480334
NCBI entrez gene - 9188     See in Manteia.
OMIM - 606357
RefSeq - XM_017016910
RefSeq - NM_001256910
RefSeq - NM_004728
RefSeq - XM_011540336
RefSeq Peptide - NP_001243839
RefSeq Peptide - NP_004719
swissprot - Q9NR30
Ensembl - ENSG00000165732
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx21ENSDARG00000063626Danio rerio
 DDX21ENSGALG00000004144Gallus gallus
 Ddx21ENSMUSG00000020075Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX50 / Q9BQ39 / DExD-box helicase 50ENSG0000010762555


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR012562  GUCT
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation HDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006366 transcription by RNA polymerase II IMP
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019843 rRNA binding IDA
 molecular_functionGO:0030515 snoRNA binding IDA
 molecular_functionGO:0035198 miRNA binding IDA
 molecular_functionGO:0097322 7SK snRNA binding IDA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117395 Q99848 / EBNA1BP2 / EBNA1 binding protein 2  / complex
 ENSG00000163938 GNL3 / Q9BVP2 / G protein nucleolar 3  / complex
 ENSG00000100029 PES1 / O00541 / pescadillo ribosomal biogenesis factor 1  / complex






 

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