ENSG00000164756


Homo sapiens

Features
Gene ID: ENSG00000164756
  
Biological name :SLC30A8
  
Synonyms : Q8IWU4 / SLC30A8 / solute carrier family 30 member 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.11
Gene start: 116950273
Gene end: 117176714
  
Corresponding Affymetrix probe sets: 1552985_at (Human Genome U133 Plus 2.0 Array)   239983_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427760
Ensembl peptide - ENSP00000485566
Ensembl peptide - ENSP00000485167
Ensembl peptide - ENSP00000431069
Ensembl peptide - ENSP00000428545
Ensembl peptide - ENSP00000407505
Ensembl peptide - ENSP00000415011
NCBI entrez gene - 169026     See in Manteia.
OMIM - 611145
RefSeq - NM_001172814
RefSeq - NM_001172815
RefSeq - NM_173851
RefSeq - NM_001172811
RefSeq - NM_001172813
RefSeq Peptide - NP_001166284
RefSeq Peptide - NP_001166286
RefSeq Peptide - NP_776250
RefSeq Peptide - NP_001166282
RefSeq Peptide - NP_001166285
swissprot - Q8IWU4
swissprot - A0A096LPF3
swissprot - A0A096LNR0
swissprot - E5RG87
Ensembl - ENSG00000164756
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent, susceptibility to}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc30a8ENSDARG00000100917Danio rerio
 SLC30A8ENSGALG00000034377Gallus gallus
 Q8BGG0ENSMUSG00000022315Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BRI3 / SLC30A2 / solute carrier family 30 member 2ENSG0000015801449
Q99726 / SLC30A3 / solute carrier family 30 member 3ENSG0000011519444
O14863 / SLC30A4 / solute carrier family 30 member 4ENSG0000010415438
Q9Y6M5 / SLC30A1 / solute carrier family 30 member 1ENSG0000017038523
Q6XR72 / SLC30A10 / solute carrier family 30 member 10ENSG0000019666021


Protein motifs (from Interpro)
Interpro ID Name
 IPR002524  Cation efflux protein
 IPR027469  Cation efflux transmembrane domain superfamily
 IPR033572  Zinc transporter 8
 IPR036837  Cation efflux protein, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006829 zinc ion transport IDA
 biological_processGO:0006882 cellular zinc ion homeostasis ISS
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0010043 response to zinc ion IBA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0032119 sequestering of zinc ion IDA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060627 regulation of vesicle-mediated transport ISS
 biological_processGO:0061088 regulation of sequestering of zinc ion IBA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IC
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Insulin processing
Zinc efflux and compartmentalization by the SLC30 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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