ENSMUSG00000022315


Mus musculus

Features
Gene ID: ENSMUSG00000022315
  
Biological name :Slc30a8
  
Synonyms : Q8BGG0 / Slc30a8 / Zinc transporter 8
  
Possible biological names infered from orthology : Q8IWU4 / solute carrier family 30 member 8
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: C
Gene start: 52295553
Gene end: 52335798
  
Corresponding Affymetrix probe sets: 10424086 (MoGene1.0st)   1444027_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035257
NCBI entrez gene - 239436     See in Manteia.
MGI - MGI:2442682
RefSeq - NM_172816
RefSeq Peptide - NP_766404
swissprot - Q8BGG0
Ensembl - ENSMUSG00000022315
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc30a8ENSDARG00000100917Danio rerio
 SLC30A8ENSGALG00000034377Gallus gallus
 Q8IWU4ENSG00000164756Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2HJ10 / Slc30a2 / solute carrier family 30 (zinc transporter), member 2 / Q9BRI3* / solute carrier family 30 member 2*ENSMUSG0000002883647
P97441 / Slc30a3 / Mus musculus solute carrier family 30 (zinc transporter), member 3 (Slc30a3), transcript variant 2, mRNA. / Q99726* / solute carrier family 30 member 3*ENSMUSG0000002915143
O35149 / Slc30a4 / Zinc transporter 4 / O14863* / solute carrier family 30 member 4*ENSMUSG0000000580238
Q60738 / Slc30a1 / solute carrier family 30 (zinc transporter), member 1 / Q9Y6M5* / solute carrier family 30 member 1*ENSMUSG0000003743424
Q3UVU3 / Slc30a10 / Zinc transporter 10 / Q6XR72* / solute carrier family 30 member 10*ENSMUSG0000002661423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002524  Cation efflux protein
 IPR027469  Cation efflux transmembrane domain superfamily
 IPR033572  Zinc transporter 8
 IPR036837  Cation efflux protein, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0006882 cellular zinc ion homeostasis IMP
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010043 response to zinc ion IBA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032119 sequestering of zinc ion IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060627 regulation of vesicle-mediated transport IEA
 biological_processGO:0061088 regulation of sequestering of zinc ion IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IBA
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Insulin processing
Zinc efflux and compartmentalization by the SLC30 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Bcar3tm1Lern/Bcar3tm1Lern
Genetic Background: B6.129S6-Bcar3tm1Lern

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Slc30a8tm1.1Htwt/Slc30a8tm1.1Htwt,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * DBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Bcar3tm1Lern/Bcar3tm1Lern
Genetic Background: B6.129S6-Bcar3tm1Lern

Allelic Composition: Slc30a8tm1.1Geno/Slc30a8tm1.1Geno
Genetic Background: involves: 129/Sv * C57BL/6JRj

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a8tm1.1Geno/Slc30a8tm1.1Geno
Genetic Background: involves: 129/Sv * C57BL/6JRj

 MP:0003839 abnormal insulin clearance "increase or decrease in the rate at which insulin is removed from the blood stream" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99786]
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Allelic Composition: Slc30a8tm1.1Htwt/Slc30a8tm1.1Htwt,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * DBA

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bpifa1m1Ingm/Bpifa1m1Ingm
Genetic Background: involves: C3HeB/FeJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Slc30a8tm1.1Htwt/Slc30a8tm1.1Htwt,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * DBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cebpbtm1Aki/Cebpbtm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009615 abnormal zinc homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcar3tm1Lern/Bcar3tm1Lern
Genetic Background: B6.129S6-Bcar3tm1Lern

Allelic Composition: Slc30a8tm1.1Geno/Slc30a8tm1.1Geno
Genetic Background: involves: 129/Sv * C57BL/6JRj

Allelic Composition: Slc30a8tm1.1Htwt/Slc30a8tm1.1Htwt,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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