ENSMUSG00000005802


Mus musculus

Features
Gene ID: ENSMUSG00000005802
  
Biological name :Slc30a4
  
Synonyms : O35149 / Slc30a4 / Zinc transporter 4
  
Possible biological names infered from orthology : O14863 / solute carrier family 30 member 4
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 122681233
Gene end: 122702663
  
Corresponding Affymetrix probe sets: 10487021 (MoGene1.0st)   1418843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005952
Ensembl peptide - ENSMUSP00000097056
NCBI entrez gene - 22785     See in Manteia.
MGI - MGI:1345282
RefSeq - NM_001290993
RefSeq - NM_011774
RefSeq Peptide - NP_001277922
RefSeq Peptide - NP_035904
swissprot - O35149
swissprot - A2AK40
Ensembl - ENSMUSG00000005802
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc30a4ENSDARG00000007180Danio rerio
 SLC30A4ENSGALG00000005703Gallus gallus
 O14863ENSG00000104154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2HJ10 / Slc30a2 / solute carrier family 30 (zinc transporter), member 2 / Q9BRI3* / solute carrier family 30 member 2*ENSMUSG0000002883634
Q8BGG0 / Slc30a8 / Zinc transporter 8 / Q8IWU4* / solute carrier family 30 member 8*ENSMUSG0000002231532
P97441 / Slc30a3 / Mus musculus solute carrier family 30 (zinc transporter), member 3 (Slc30a3), transcript variant 2, mRNA. / Q99726* / solute carrier family 30 member 3*ENSMUSG0000002915130
Q3UVU3 / Slc30a10 / Zinc transporter 10 / Q6XR72* / solute carrier family 30 member 10*ENSMUSG0000002661419
Q60738 / Slc30a1 / solute carrier family 30 (zinc transporter), member 1 / Q9Y6M5* / solute carrier family 30 member 1*ENSMUSG0000003743419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002524  Cation efflux protein
 IPR027469  Cation efflux transmembrane domain superfamily
 IPR036837  Cation efflux protein, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010043 response to zinc ion IBA
 biological_processGO:0055069 zinc ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061088 regulation of sequestering of zinc ion IEA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IBA
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0002894 abnormal otoliths "malformed crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0004812 abnormal linear vestibular evoked potential "anomaly in the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0009599 thick epidermis stratum granulosum "increased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0009615 abnormal zinc homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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