ENSMUSG00000026614


Mus musculus

Features
Gene ID: ENSMUSG00000026614
  
Biological name :Slc30a10
  
Synonyms : Q3UVU3 / Slc30a10 / Zinc transporter 10
  
Possible biological names infered from orthology : Q6XR72 / solute carrier family 30 member 10
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 185454848
Gene end: 185468762
  
Corresponding Affymetrix probe sets: 10352548 (MoGene1.0st)   1438751_at (Mouse Genome 430 2.0 Array)   1439934_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053181
NCBI entrez gene - 226781     See in Manteia.
MGI - MGI:2685058
RefSeq - NM_001033286
RefSeq Peptide - NP_001028458
swissprot - Q3UVU3
Ensembl - ENSMUSG00000026614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc30a10ENSDARG00000103983Danio rerio
 SLC30A10ENSGALG00000026727Gallus gallus
 Q6XR72ENSG00000196660Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60738 / Slc30a1 / solute carrier family 30 (zinc transporter), member 1 / Q9Y6M5* / solute carrier family 30 member 1*ENSMUSG0000003743436
Q8BGG0 / Slc30a8 / Zinc transporter 8 / Q8IWU4* / solute carrier family 30 member 8*ENSMUSG0000002231518
O35149 / Slc30a4 / Zinc transporter 4 / O14863* / solute carrier family 30 member 4*ENSMUSG0000000580218
P97441 / Slc30a3 / Mus musculus solute carrier family 30 (zinc transporter), member 3 (Slc30a3), transcript variant 2, mRNA. / Q99726* / solute carrier family 30 member 3*ENSMUSG0000002915117
Q2HJ10 / Slc30a2 / solute carrier family 30 (zinc transporter), member 2 / Q9BRI3* / solute carrier family 30 member 2*ENSMUSG0000002883617


Protein motifs (from Interpro)
Interpro ID Name
 IPR002524  Cation efflux protein
 IPR027469  Cation efflux transmembrane domain superfamily
 IPR036837  Cation efflux protein, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006828 manganese ion transport IEA
 biological_processGO:0006829 zinc ion transport IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0010043 response to zinc ion IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061088 regulation of sequestering of zinc ion IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:0071577 zinc ion transmembrane transport IEA
 biological_processGO:0071579 regulation of zinc ion transport IEA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1905802 regulation of cellular response to manganese ion IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005385 zinc ion transmembrane transporter activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Metal ion SLC transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0003503 decreased activity of thyroid 
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0006350 increased circulating copper level "greater than normal concentration of copper in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

 MP:0020365 increased brain iron level "increase in the amount of iron present in the brain tissue" [MGI:Anna]
Show

Allelic Composition: Abca4tm1.1Rsmy/Abca4tm1.1Rsmy
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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