ENSG00000166823


Homo sapiens

Features
Gene ID: ENSG00000166823
  
Biological name :MESP1
  
Synonyms : mesoderm posterior bHLH transcription factor 1 / MESP1 / Q9BRJ9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q26.1
Gene start: 89748661
Gene end: 89751310
  
Corresponding Affymetrix probe sets: 224476_s_at (Human Genome U133 Plus 2.0 Array)   229195_at (Human Genome U133 Plus 2.0 Array)   243387_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300057
NCBI entrez gene - 55897     See in Manteia.
OMIM - 608689
RefSeq - NM_018670
RefSeq Peptide - NP_061140
swissprot - Q9BRJ9
Ensembl - ENSG00000166823
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mespbaENSDARG00000030347Danio rerio
 mespbbENSDARG00000097947Danio rerio
 ENSGALG00000008275Gallus gallus
 MESP1ENSGALG00000026467Gallus gallus
 Mesp1ENSMUSG00000030544Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MESP2 / Q0VG99 / mesoderm posterior bHLH transcription factor 2ENSG0000018809546
MSGN1 / A6NI15 / mesogenin 1ENSG0000015137919


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IBA
 biological_processGO:0001756 somitogenesis IBA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003143 embryonic heart tube morphogenesis IEA
 biological_processGO:0003210 cardiac atrium formation IMP
 biological_processGO:0003211 cardiac ventricle formation IMP
 biological_processGO:0003236 sinus venosus morphogenesis IEA
 biological_processGO:0003241 growth involved in heart morphogenesis IEA
 biological_processGO:0003259 cardioblast anterior-lateral migration IEA
 biological_processGO:0003260 cardioblast migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0008078 mesodermal cell migration IEA
 biological_processGO:0009880 embryonic pattern specification IBA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0035481 positive regulation of Notch signaling pathway involved in heart induction IEA
 biological_processGO:0042662 negative regulation of mesodermal cell fate specification IEA
 biological_processGO:0042664 negative regulation of endodermal cell fate specification IEA
 biological_processGO:0045446 endothelial cell differentiation IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048368 lateral mesoderm development IEA
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060913 cardiac cell fate determination IEA
 biological_processGO:0060921 sinoatrial node cell differentiation IMP
 biological_processGO:0060947 cardiac vascular smooth muscle cell differentiation IMP
 biological_processGO:0060975 cardioblast migration to the midline involved in heart field formation IEA
 biological_processGO:0070368 positive regulation of hepatocyte differentiation IEA
 biological_processGO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0035326 enhancer binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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