| MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm8Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm9Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * SJL
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA * SJL
Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Rbpjtm1Hon/Rbpjtm1Hon,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
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| MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Nodaltm1Mku/Nodaltm1Mku,Mesp1tm2(cre)Ysa/Mesp1+,Tg(Pitx2-lacZ)1Mbf/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: B6.Cg-Mesp1tm2(cre)Ysa Kmt2dtm1.1Kaig
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| MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA * SJL
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| MP:0000277 | abnormal heart shape | "malformation of the form or the patterning of the heart" [J:18048] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * SJL
Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dad1tm1Brw/Dad1tm1Brw
Genetic Background: involves: 129P2/OlaHsd * Black Swiss
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| MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0000705 | athymia | "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm5Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001068 | abnormal mandibular nerve branching | "malformed or misprojected axons of the mandibular nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001074 | abnormal vagus nerve morphology | "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001075 | abnormal accessory nerve morphology | "any malformation or misprojection of the 11th cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0001675 | abnormal ectoderm development | "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Mesp1tm1Ysa/Mesp1tm3Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0001683 | absent mesoderm | "missing or failure to differentiate the middle primary germ layer " [J:40594] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0001685 | abnormal endoderm development | "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001695 | abnormal gastrulation | "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Dad1tm1Brw/Dad1tm1Brw
Genetic Background: involves: 129P2/OlaHsd * Black Swiss
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Braftm1Mmcm/Braf+,Tg(Tg-cre/ERT2)#Mmcm/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002088 | abnormal embryonic growth/weight/body size | "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zic3tm2.1Jwb/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6J * CBA/J
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| MP:0002189 | abnormal myocardial trabeculae morphology | "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0002230 | abnormal primitive streak formation | "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi,Msx1tm1Bero/Msx1tm1Bero
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002231 | abnormal primitive streak morphology | "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Mesp1tm1Ysa/Mesp1tm3Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0002621 | delayed neural tube closure | "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
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| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0002884 | abnormal branchial arches | "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002925 | abnormal cardiovascular development | "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission] |
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Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002950 | abnormal neural crest cell migration | "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm5Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0003649 | reduced right ventricle | |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0003679 | ear lobe hypoplasia | "a decrease in the number of cells in the ear lobes" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: B6.Cg-Mesp1tm2(cre)Ysa Kmt2dtm1.1Kaig
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| MP:0003988 | disorganized embryonic tissue | "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080] |
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Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ
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| MP:0004067 | abnormal ventricular trabeculae morphology | "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
|
| MP:0004090 | abnormal sarcomere morphology | "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0004110 | transposition of great arteries | "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0004113 | abnormal aortic arch morphology | "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0004180 | failure of initiation of embryo turning | "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0004187 | cardia bifida | "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0004188 | delayed embryo turning | "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
|
| MP:0004555 | pharynx hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells,of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004569 | glossopharyngeal nerve hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0004837 | abnormal neural fold formation | "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0006207 | embryonic lethality during organogenesis | "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * SJL
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| MP:0006301 | abnormal mesenchyme morphology | "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0006354 | abnormal fourth branchial arch artery morphology | "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0006355 | abnormal sixth branchial arch artery morphology | "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chd7Gt(XK403)Byg/Chd7+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1)
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0006356 | abnormal third branchial arch artery morphology | "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0006386 | absent somites | "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0008029 | abnormal paraxial mesoderm | "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0008825 | abnormal cardiac epithelial to mesenchymal transition | "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * SJL
Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0009490 | abnormal heart left atrium auricular region morphology | "any structural anomaly of the small conical muscular projection connected to the left atrium of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: involves: C57BL/6J
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010406 | absent atrial septum | "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0010412 | atrioventricular septal defect | "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
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| MP:0010422 | heart right ventricle hypoplasia | "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grm6nob4/Grm6nob4
Genetic Background: involves: C57BL/6J
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| MP:0010432 | common ventricle | "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0010465 | aberrant origin of the right subclavian artery | "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0010484 | bicuspid aortic valve | "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified
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| MP:0010503 | myocardial trabeculae hypoplasia | "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Pofut1tm1Ysa/Pofut1tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * SJL
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| MP:0010527 | bicuspid pulmonary valve | "the presence of two cusps or leaflets in the pulmonary valve instead of three" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0010642 | absent third branchial arch | "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0010643 | absent fourth branchial arch | "absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm5Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0010644 | absent sixth branchial arch | "absence of the structure of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Dph1tm2Bhr/Dph1+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
Allelic Composition: Mesp1tm3Ysa/Mesp1tm3Ysa,Mesp2tm3(cre)Ysa/Mesp2tm3(cre)Ysa
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: C3H * C57BL/6 * CBA
Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: B6.Cg-Mesp1tm2(cre)Ysa Kmt2dtm1.1Kaig
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6 * CBA
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| MP:0011112 | partial lethality during fetal growth through weaning | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
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| MP:0011388 | absent heart | "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb] |
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Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ
Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0011732 | decreased somite size | "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0012184 | absent paraxial mesoderm | "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna] |
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR
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| MP:0012278 | abnormal cardiogenic mesoderm morphology | "any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [MGI:anna] |
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Allelic Composition: Egr2tm1Pch/Egr2tm1Pch
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
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| MP:0012729 | abnormal common carotid artery morphology | "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna] |
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Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0012752 | abnormal cardiac neural crest cell migration | "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0012757 | abnormal cranial neural crest cell migration | "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0013265 | abnormal fourth pharyngeal pouch morphology | "any structural anomaly of the fourth endodermal branchial pouch located between the fourth and sixth branchial arches (a fifth arch never establishes itself in amniotes); in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland (the parathyroid glands derived from the third pouches descend with the thymus and are carried to a more inferior position than the parathyroid glands that are derived from the fourth pouches); the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland" [MGI:anna, PMID:20144910] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0013268 | second pharyngeal arch hypoplasia | "underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0013269 | third pharyngeal arch hypoplasia | "underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number" [MGI:anna] |
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Allelic Composition: Fgf10tm1Ska/Fgf10tm1Ska,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Fgf10tm1Ska/Fgf10+,Fgf8tm1Moon/Fgf8tm1Moon,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0030334 | absent sixth pharyngeal arch artery | "failure to develop or absence of the sixth pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0030335 | absent third pharyngeal arch artery | "failure to develop or absence of the third pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0030340 | absent fourth pharyngeal arch artery | "failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tbx1tm1Bld/Tbx1tm5Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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