ENSMUSG00000030543


Mus musculus

Features
Gene ID: ENSMUSG00000030543
  
Biological name :Mesp2
  
Synonyms : mesoderm posterior bHLH transcription factor 2 / Mesp2
  
Possible biological names infered from orthology : Q0VG99
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D2
Gene start: 79810727
Gene end: 79813439
  
Corresponding Affymetrix probe sets: 10554367 (MoGene1.0st)   1419629_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103017
NCBI entrez gene - 17293     See in Manteia.
MGI - MGI:1096325
RefSeq - NM_008589
RefSeq Peptide - NP_032615
swissprot - A6H5V4
Ensembl - ENSMUSG00000030543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mespbaENSDARG00000030347Danio rerio
 mespbbENSDARG00000097947Danio rerio
 ENSGALG00000008275Gallus gallus
 MESP1ENSGALG00000026467Gallus gallus
 MESP2ENSG00000188095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mesp1 / P97309 / Mesoderm posterior protein 1 / Q9BRJ9* / mesoderm posterior bHLH transcription factor 1*ENSMUSG0000003054427
Msgn1 / Q9JK54 / Mesogenin-1 / A6NI15*ENSMUSG0000004700213


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1pe/Ap3b1pe
Genetic Background: B6.C3-Ap3b1pe/J

Allelic Composition: Mesp2tm10Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm12Ysa/Mesp2tm12Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

Allelic Composition: Mesp2tm17.1(VP16/Rbpj)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm13(cre/Esr1*)Ysa/Mesp2+
Genetic Background: Not Specified

Allelic Composition: Mesp2tm13(cre/Esr1*)Ysa/Mesp2+
Genetic Background: involves: C57BL/6J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: EnamRgsc521/Enam+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: EnamRgsc521/Enam+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: Mesp2tm7(mespb)Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp2tm8Ysa/Mesp2tm8Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm9Ysa/Mesp2tm9Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm8Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm9Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm12Ysa/Mesp2tm12Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1pe/Ap3b1pe
Genetic Background: B6.C3-Ap3b1pe/J

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: EnamRgsc521/Enam+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm7(mespb)Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13(cre/Esr1*)Ysa/Mesp2tm13(cre/Esr1*)Ysa
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

Allelic Composition: Mesp2tm15.1(Lfng)Ysa/Mesp2tm15.1(Lfng)Ysa
Genetic Background: Not Specified

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: involves: C57BL/6 * SJL

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
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Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EnamRgsc521/Enam+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smpd3fro/Smpd3fro
Genetic Background: C3H.Cg-Smpd3fro

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002632 vestigial tail "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa,Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm5(Notch1)Ysa/Mesp2tm5(Notch1)Ysa,Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6 * CBA

 MP:0004600 abnormal vertebral transverse process "any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004604 abnormal vertebral pedicle morphology "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004605 abnormal vertebral lamina morphology "any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm4Ysa/Mesp2tm4Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm7(mespb)Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm17.1(VP16/Rbpj)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp2tm11Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1+,Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm10Ysa/Mesp2tm11Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004683 absent intervertebral disk "absence of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm12Ysa/Mesp2tm12Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
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Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mesp2tm10Ysa/Mesp2tm10Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mesp2tm12Ysa/Mesp2tm12Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm7(mespb)Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: Not Specified

Allelic Composition: Mesp2tm17.1(VP16/Rbpj)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Mesp1tm3Ysa/Mesp1tm3Ysa,Mesp2tm3(cre)Ysa/Mesp2tm3(cre)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
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Allelic Composition: Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0012728 abnormal somite border morphology "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

Allelic Composition: Mesp2tm7(mespb)Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm7.1(mespb)Ysa
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mesp2tm1Ysa/Mesp2tm1Ysa
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm13.1(cre/Esr1*)Ysa
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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