ENSMUSG00000047002


Mus musculus

Features
Gene ID: ENSMUSG00000047002
  
Biological name :Msgn1
  
Synonyms : Mesogenin-1 / Msgn1 / Q9JK54
  
Possible biological names infered from orthology : A6NI15
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 11208360
Gene end: 11208972
  
Corresponding Affymetrix probe sets: 10399387 (MoGene1.0st)   1421798_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055001
NCBI entrez gene - 56184     See in Manteia.
MGI - MGI:1860483
RefSeq - NM_019544
RefSeq Peptide - NP_062417
swissprot - Q9JK54
Ensembl - ENSMUSG00000047002
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msgn1ENSDARG00000070546Danio rerio
 MSGN1ENSGALG00000016469Gallus gallus
 MSGN1ENSG00000151379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mesp1 / P97309 / Mesoderm posterior protein 1 / Q9BRJ9* / mesoderm posterior bHLH transcription factor 1*ENSMUSG0000003054427
Mesp2 / mesoderm posterior bHLH transcription factor 2 / Q0VG99*ENSMUSG0000003054326


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IBA
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007379 segment specification IMP
 biological_processGO:0009880 embryonic pattern specification IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000138 absent vertebrae "missing bony segments of the spinal column" [J:35802]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000151 absent rib "missing the pairs of bony structures that make up the body wall" [J:19212]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003401 enlarged tail bud "increased size or area of the primordial region of the embryo that arises to form the tail of the adult" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0004197 abnormal fetal growth/weight/body size "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0012182 abnormal presomitic mesoderm morphology "any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0012277 increased tail bud apoptosis "increased number of cells undergoing programmed cell death in the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0012707 incomplete caudal neuropore closure "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [MGI:anna]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr