ENSG00000167900


Homo sapiens

Features
Gene ID: ENSG00000167900
  
Biological name :TK1
  
Synonyms : P04183 / thymidine kinase 1 / TK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 78174075
Gene end: 78187233
  
Corresponding Affymetrix probe sets: 1554408_a_at (Human Genome U133 Plus 2.0 Array)   202338_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467121
Ensembl peptide - ENSP00000468425
Ensembl peptide - ENSP00000468556
Ensembl peptide - ENSP00000301634
Ensembl peptide - ENSP00000468278
NCBI entrez gene - 7083     See in Manteia.
OMIM - 188300
RefSeq - XM_017024992
RefSeq - NM_003258
RefSeq Peptide - NP_003249
swissprot - K7ERV3
swissprot - K7ES52
swissprot - K7ENW5
swissprot - P04183
swissprot - K7ERJ1
Ensembl - ENSG00000167900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tk1ENSDARG00000102245Danio rerio
 TK1ENSGALG00000007191Gallus gallus
 Tk1ENSMUSG00000025574Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001267  Thymidine kinase
 IPR020633  Thymidine kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006259 DNA metabolic process IBA
 biological_processGO:0009157 deoxyribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043097 pyrimidine nucleoside salvage TAS
 biological_processGO:0046104 thymidine metabolic process IBA
 biological_processGO:0051289 protein homotetramerization IPI
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004797 thymidine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019206 nucleoside kinase activity EXP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of E2F1 target genes at G1/S
Pyrimidine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167900 TK1 / P04183 / thymidine kinase 1  / complex






 

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