ENSMUSG00000025574


Mus musculus

Features
Gene ID: ENSMUSG00000025574
  
Biological name :Tk1
  
Synonyms : P04184 / thymidine kinase 1 / Tk1
  
Possible biological names infered from orthology : P04183
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 117815526
Gene end: 117826092
  
Corresponding Affymetrix probe sets: 10393431 (MoGene1.0st)   10582809 (MoGene1.0st)   1416258_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026661
NCBI entrez gene - 21877     See in Manteia.
MGI - MGI:98763
RefSeq - XM_006533151
RefSeq - NM_001271729
RefSeq - NM_009387
RefSeq - XM_006533149
RefSeq - XM_006533150
RefSeq Peptide - NP_001258658
RefSeq Peptide - NP_033413
swissprot - P04184
Ensembl - ENSMUSG00000025574
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tk1ENSDARG00000102245Danio rerio
 TK1ENSGALG00000007191Gallus gallus
 TK1ENSG00000167900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001267  Thymidine kinase
 IPR020633  Thymidine kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IBA
 biological_processGO:0009157 deoxyribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046104 thymidine metabolic process IBA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004797 thymidine kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019206 nucleoside kinase activity ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pyrimidine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tk1tm1Vnd/Tk1tm1Vnd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0003504 thyroid inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0003991 arteriosclerosis "thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0004035 abnormal sublingual gland morphology "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: at-43J/at-43J
Genetic Background: involves: C3HeB/FeJLe

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Tk1tm1Vnd/Tk1tm1Vnd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025574 Tk1 / P04184 / thymidine kinase 1 / P04183*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr