ENSG00000168779


Homo sapiens

Features
Gene ID: ENSG00000168779
  
Biological name :SHOX2
  
Synonyms : O60902 / short stature homeobox 2 / SHOX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.32
Gene start: 158095954
Gene end: 158106503
  
Corresponding Affymetrix probe sets: 208443_x_at (Human Genome U133 Plus 2.0 Array)   210134_x_at (Human Genome U133 Plus 2.0 Array)   210135_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479329
Ensembl peptide - ENSP00000397099
Ensembl peptide - ENSP00000398704
Ensembl peptide - ENSP00000419362
Ensembl peptide - ENSP00000374240
NCBI entrez gene - 6474     See in Manteia.
OMIM - 602504
RefSeq - XM_017007055
RefSeq - NM_003030
RefSeq - NM_006884
RefSeq - XM_006713727
RefSeq - XM_006713728
RefSeq - XM_017007053
RefSeq - XM_017007054
RefSeq - NM_001163678
RefSeq Peptide - NP_006875
RefSeq Peptide - NP_001157150
RefSeq Peptide - NP_003021
swissprot - A6NLG4
swissprot - O60902
swissprot - A0A087WVB7
Ensembl - ENSG00000168779
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shox2ENSDARG00000075713Danio rerio
 Shox2ENSMUSG00000027833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHOX / O15266 / short stature homeoboxENSG0000018596055
OTP / Q5XKR4 / orthopedia homeoboxENSG0000017154021
ESX1 / Q8N693 / ESX homeobox 1ENSG0000012357619
P0C7M4 / RHOXF2B / Rhox homeobox family member 2BENSG0000020398915
Q9BQY4 / RHOXF2 / Rhox homeobox family member 2ENSG0000013172115
Q8NHV9 / RHOXF1 / Rhox homeobox family member 1ENSG0000010188312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0003170 heart valve development IEA
 biological_processGO:0003209 cardiac atrium morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007507 heart development TAS
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0032330 regulation of chondrocyte differentiation IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IEA
 biological_processGO:0060351 cartilage development involved in endochondral bone morphogenesis IEA
 biological_processGO:0060415 muscle tissue morphogenesis IEA
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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