ENSG00000170525


Homo sapiens

Features
Gene ID: ENSG00000170525
  
Biological name :PFKFB3
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / PFKFB3 / Q16875
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 6144934
Gene end: 6254644
  
Corresponding Affymetrix probe sets: 202464_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000487277
Ensembl peptide - ENSP00000486311
Ensembl peptide - ENSP00000491095
Ensembl peptide - ENSP00000492001
Ensembl peptide - ENSP00000353712
Ensembl peptide - ENSP00000369100
Ensembl peptide - ENSP00000369105
Ensembl peptide - ENSP00000369111
Ensembl peptide - ENSP00000369115
Ensembl peptide - ENSP00000390285
Ensembl peptide - ENSP00000404995
Ensembl peptide - ENSP00000416677
Ensembl peptide - ENSP00000432356
Ensembl peptide - ENSP00000433771
Ensembl peptide - ENSP00000434342
Ensembl peptide - ENSP00000434628
Ensembl peptide - ENSP00000436885
Ensembl peptide - ENSP00000443319
NCBI entrez gene - 5209     See in Manteia.
OMIM - 605319
RefSeq - XM_017016329
RefSeq - NM_001145443
RefSeq - NM_001282630
RefSeq - NM_001314063
RefSeq - NM_001323016
RefSeq - NM_001323017
RefSeq - NM_004566
RefSeq - XM_005252464
RefSeq - XM_011519493
RefSeq - XM_017016325
RefSeq - XM_017016326
RefSeq - XM_017016327
RefSeq - XM_017016328
RefSeq Peptide - NP_001300992
RefSeq Peptide - NP_001309945
RefSeq Peptide - NP_001309946
RefSeq Peptide - NP_004557
RefSeq Peptide - NP_001138915
RefSeq Peptide - NP_001269559
swissprot - H0Y483
swissprot - H0YDV0
swissprot - Q16875
swissprot - Q5VX20
swissprot - Q5W015
swissprot - Q9BQU1
swissprot - Q9H178
swissprot - A0A1W2PNV9
swissprot - A0A1W2PR17
swissprot - F2Z2I2
Ensembl - ENSG00000170525
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb3ENSDARG00000001953Danio rerio
 PFKFB3ENSGALG00000040369Gallus gallus
 Pfkfb3ENSMUSG00000026773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60825 / PFKFB2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2ENSG0000012383663
P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1ENSG0000015857159
PFKFB4 / Q16877 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4ENSG0000011426859


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0045821 positive regulation of glycolytic process TAS
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity IEA
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170525 PFKFB3 / Q16875 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3  / complex






 

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