ENSMUSG00000026773


Mus musculus

Features
Gene ID: ENSMUSG00000026773
  
Biological name :Pfkfb3
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / Pfkfb3
  
Possible biological names infered from orthology : Q16875
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 11471433
Gene end: 11554077
  
Corresponding Affymetrix probe sets: 10480035 (MoGene1.0st)   1416432_at (Mouse Genome 430 2.0 Array)   1456676_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110493
Ensembl peptide - ENSMUSP00000110494
Ensembl peptide - ENSMUSP00000142296
Ensembl peptide - ENSMUSP00000142079
Ensembl peptide - ENSMUSP00000141445
Ensembl peptide - ENSMUSP00000138893
Ensembl peptide - ENSMUSP00000137130
Ensembl peptide - ENSMUSP00000129122
Ensembl peptide - ENSMUSP00000126305
Ensembl peptide - ENSMUSP00000110495
Ensembl peptide - ENSMUSP00000028114
Ensembl peptide - ENSMUSP00000050926
Ensembl peptide - ENSMUSP00000097979
NCBI entrez gene - 170768     See in Manteia.
MGI - MGI:2181202
RefSeq - XM_017315954
RefSeq - NM_001177752
RefSeq - NM_001177753
RefSeq - NM_001177754
RefSeq - NM_001177755
RefSeq - NM_001177756
RefSeq - NM_001177757
RefSeq - NM_001177758
RefSeq - NM_133232
RefSeq - XM_006497367
RefSeq - XM_006497368
RefSeq - XM_006497369
RefSeq Peptide - NP_001171229
RefSeq Peptide - NP_573495
RefSeq Peptide - NP_001171223
RefSeq Peptide - NP_001171224
RefSeq Peptide - NP_001171225
RefSeq Peptide - NP_001171226
RefSeq Peptide - NP_001171227
RefSeq Peptide - NP_001171228
swissprot - A7UAK5
swissprot - A7UAK4
swissprot - A2AUP5
swissprot - A2AUP4
swissprot - A2AUP3
swissprot - Q3U3S6
swissprot - Q7TS91
swissprot - A7UAK8
swissprot - A2AUP1
swissprot - A0A0A6YY64
swissprot - A0A0A6YW89
Ensembl - ENSMUSG00000026773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb3ENSDARG00000001953Danio rerio
 PFKFB3ENSGALG00000040369Gallus gallus
 PFKFB3ENSG00000170525Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pfkfb2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 / O60825*ENSMUSG0000002640961
Pfkfb4 / Q6DTY7 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / Q16877*ENSMUSG0000002564858
P70266 / Pfkfb1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P16118*ENSMUSG0000002527156
Gm29427 / O60825* / PFKFB2* / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2*ENSMUSG0000010190446


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity ISO
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0012201 decreased endothelial cell proliferation 
Show

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Pfkfb3tm1Pec/Pfkfb3tm1Pec,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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