ENSMUSG00000026409


Mus musculus

Features
Gene ID: ENSMUSG00000026409
  
Biological name :Pfkfb2
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 / Pfkfb2
  
Possible biological names infered from orthology : O60825
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 130689182
Gene end: 130729253
  
Corresponding Affymetrix probe sets: 10357535 (MoGene1.0st)   1422090_a_at (Mouse Genome 430 2.0 Array)   1422091_at (Mouse Genome 430 2.0 Array)   1422092_at (Mouse Genome 430 2.0 Array)   1429486_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140068
Ensembl peptide - ENSMUSP00000140995
Ensembl peptide - ENSMUSP00000140984
Ensembl peptide - ENSMUSP00000140799
Ensembl peptide - ENSMUSP00000140698
Ensembl peptide - ENSMUSP00000140612
Ensembl peptide - ENSMUSP00000140551
Ensembl peptide - ENSMUSP00000140355
Ensembl peptide - ENSMUSP00000066426
Ensembl peptide - ENSMUSP00000127587
Ensembl peptide - ENSMUSP00000129747
Ensembl peptide - ENSMUSP00000133073
NCBI entrez gene - 18640     See in Manteia.
MGI - MGI:107815
RefSeq - NM_001162416
RefSeq - NM_008825
RefSeq - NM_001162415
RefSeq Peptide - NP_001155887
RefSeq Peptide - NP_001155888
RefSeq Peptide - NP_032851
swissprot - B2Z894
swissprot - Q6GTL7
swissprot - B2Z893
swissprot - B2Z892
swissprot - B2Z891
swissprot - A0A087WRW5
swissprot - A0A087WRM7
swissprot - A0A087WRG0
Ensembl - ENSMUSG00000026409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb2aENSDARG00000023840Danio rerio
 pfkfb2bENSDARG00000002037Danio rerio
 PFKFB2ENSGALG00000001117Gallus gallus
 O60825ENSG00000123836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm29427 / O60825* / PFKFB2* / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2*ENSMUSG0000010190471
Pfkfb3 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / Q16875*ENSMUSG0000002677365
P70266 / Pfkfb1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P16118*ENSMUSG0000002527159
Pfkfb4 / Q6DTY7 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / Q16877*ENSMUSG0000002564859


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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