ENSMUSG00000025648


Mus musculus

Features
Gene ID: ENSMUSG00000025648
  
Biological name :Pfkfb4
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / Pfkfb4 / Q6DTY7
  
Possible biological names infered from orthology : Q16877
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108991778
Gene end: 109032228
  
Corresponding Affymetrix probe sets: 10589329 (MoGene1.0st)   1456888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057197
Ensembl peptide - ENSMUSP00000142378
Ensembl peptide - ENSMUSP00000142992
Ensembl peptide - ENSMUSP00000143249
Ensembl peptide - ENSMUSP00000142339
NCBI entrez gene - 270198     See in Manteia.
MGI - MGI:2687284
RefSeq - XM_017313404
RefSeq - XM_006512137
RefSeq - XM_006512138
RefSeq - XM_017313402
RefSeq - XM_017313403
RefSeq - NM_173019
RefSeq - XM_006512133
RefSeq - XM_006512134
RefSeq - XM_006512135
RefSeq Peptide - NP_766607
swissprot - A0A0G2JFP0
swissprot - A0A0G2JDE6
swissprot - Q6DTY7
Ensembl - ENSMUSG00000025648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb4aENSDARG00000055540Danio rerio
 pfkfb4bENSDARG00000029075Danio rerio
 PFKFB4ENSGALG00000002099Gallus gallus
 PFKFB4ENSG00000114268Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70266 / Pfkfb1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P16118*ENSMUSG0000002527171
Pfkfb3 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / Q16875*ENSMUSG0000002677369
Pfkfb2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 / O60825*ENSMUSG0000002640965
Gm29427 / O60825* / PFKFB2* / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2*ENSMUSG0000010190450


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity ISO
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025648 Pfkfb4 / Q6DTY7 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / Q16877*  / complex






 

1 s.

 
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