ENSG00000171311


Homo sapiens

Features
Gene ID: ENSG00000171311
  
Biological name :EXOSC1
  
Synonyms : EXOSC1 / exosome component 1 / Q9Y3B2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 97436142
Gene end: 97446017
  
Corresponding Affymetrix probe sets: 1559044_at (Human Genome U133 Plus 2.0 Array)   218369_s_at (Human Genome U133 Plus 2.0 Array)   222609_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359923
Ensembl peptide - ENSP00000359922
Ensembl peptide - ENSP00000359939
Ensembl peptide - ENSP00000473660
Ensembl peptide - ENSP00000473303
Ensembl peptide - ENSP00000359921
NCBI entrez gene - 51013     See in Manteia.
OMIM - 606493
RefSeq - XM_017016304
RefSeq - NM_001318362
RefSeq - NM_001318363
RefSeq - NM_001318364
RefSeq - NM_001318365
RefSeq - NM_001318366
RefSeq - NM_016046
RefSeq - XM_011539847
RefSeq Peptide - NP_001305292
RefSeq Peptide - NP_001305295
RefSeq Peptide - NP_057130
RefSeq Peptide - NP_001305293
RefSeq Peptide - NP_001305294
RefSeq Peptide - NP_001305291
swissprot - R4GNH9
swissprot - B1AMU7
swissprot - B1AMU4
swissprot - Q9Y3B2
swissprot - R4GMQ7
swissprot - B1AMU3
Ensembl - ENSG00000171311
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc1ENSDARG00000059841Danio rerio
 EXOSC1ENSGALG00000039917Gallus gallus
 Exosc1ENSMUSG00000034321Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR019495  Exosome complex component CSL4
 IPR022967  RNA-binding domain, S1
 IPR025721  Exosome complex component, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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