ENSG00000172340


Homo sapiens

Features
Gene ID: ENSG00000172340
  
Biological name :SUCLG2
  
Synonyms : Q96I99 / succinate-CoA ligase GDP-forming beta subunit / SUCLG2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.1
Gene start: 67360460
Gene end: 67654614
  
Corresponding Affymetrix probe sets: 212459_x_at (Human Genome U133 Plus 2.0 Array)   214835_s_at (Human Genome U133 Plus 2.0 Array)   215772_x_at (Human Genome U133 Plus 2.0 Array)   215774_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417589
Ensembl peptide - ENSP00000419325
Ensembl peptide - ENSP00000307432
Ensembl peptide - ENSP00000417260
NCBI entrez gene - 8801     See in Manteia.
OMIM - 603922
RefSeq - XM_017007420
RefSeq - NM_003848
RefSeq - XM_017007415
RefSeq - XM_017007416
RefSeq - XM_017007417
RefSeq - XM_017007418
RefSeq - XM_017007419
RefSeq - NM_001177599
RefSeq Peptide - NP_001171070
RefSeq Peptide - NP_003839
swissprot - E9PDQ8
swissprot - H0Y852
swissprot - Q96I99
swissprot - A0A024R325
Ensembl - ENSG00000172340
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 suclg2ENSDARG00000044914Danio rerio
 SUCLG2ENSGALG00000007652Gallus gallus
 Q9Z2I8ENSMUSG00000061838Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9P2R7 / SUCLA2 / succinate-CoA ligase ADP-forming beta subunitENSG0000013614347


Protein motifs (from Interpro)
Interpro ID Name
 IPR005809  Succinate--CoA synthetase, beta subunit
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR013650  ATP-grasp fold, succinyl-CoA synthetase-type
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016102  Succinyl-CoA synthetase-like
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR034722  Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006104 succinyl-CoA metabolic process NAS
 biological_processGO:0006105 succinate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0045244 succinate-CoA ligase complex (GDP-forming) IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004775 succinate-CoA ligase (ADP-forming) activity IEA
 molecular_functionGO:0004776 succinate-CoA ligase (GDP-forming) activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163541 P53597 / SUCLG1 / succinate-CoA ligase alpha subunit  / complex






 

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