ENSMUSG00000061838


Mus musculus

Features
Gene ID: ENSMUSG00000061838
  
Biological name :Suclg2
  
Synonyms : Q9Z2I8 / Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial / Suclg2
  
Possible biological names infered from orthology : Q96I99 / succinate-CoA ligase GDP-forming beta subunit
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D2
Gene start: 95473009
Gene end: 95718800
  
Corresponding Affymetrix probe sets: 10546538 (MoGene1.0st)   10607497 (MoGene1.0st)   1427441_a_at (Mouse Genome 430 2.0 Array)   1435841_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078774
Ensembl peptide - ENSMUSP00000144827
Ensembl peptide - ENSMUSP00000145471
NCBI entrez gene - 20917     See in Manteia.
MGI - MGI:1306824
RefSeq - XM_017321481
RefSeq - NM_001326558
RefSeq - NM_011507
RefSeq Peptide - NP_001313487
RefSeq Peptide - NP_035637
swissprot - Q9Z2I8
swissprot - A0A0N4SWD1
Ensembl - ENSMUSG00000061838
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 suclg2ENSDARG00000044914Danio rerio
 SUCLG2ENSGALG00000007652Gallus gallus
 Q96I99ENSG00000172340Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z2I9 / Sucla2 / Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial / Q9P2R7* / succinate-CoA ligase ADP-forming beta subunit*ENSMUSG0000002211050


Protein motifs (from Interpro)
Interpro ID Name
 IPR005809  Succinate--CoA synthetase, beta subunit
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR011761  ATP-grasp fold
 IPR013650  ATP-grasp fold, succinyl-CoA synthetase-type
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016102  Succinyl-CoA synthetase-like
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR034722  Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006104 succinyl-CoA metabolic process IEA
 biological_processGO:0006105 succinate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0045244 succinate-CoA ligase complex (GDP-forming) IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004776 succinate-CoA ligase (GDP-forming) activity IEA
 molecular_functionGO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity ISA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+
Genetic Background: involves: 129S/SvEv * C57BL/6N

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052738 Q9WUM5 / Suclg1 / Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial / P53597* / succinate-CoA ligase alpha subunit*  / complex






 

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