ENSMUSG00000022110


Mus musculus

Features
Gene ID: ENSMUSG00000022110
  
Biological name :Sucla2
  
Synonyms : Q9Z2I9 / Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial / Sucla2
  
Possible biological names infered from orthology : Q9P2R7 / succinate-CoA ligase ADP-forming beta subunit
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D3
Gene start: 73525319
Gene end: 73596142
  
Corresponding Affymetrix probe sets: 10416379 (MoGene1.0st)   1430402_at (Mouse Genome 430 2.0 Array)   1447056_at (Mouse Genome 430 2.0 Array)   1452206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022706
Ensembl peptide - ENSMUSP00000123765
Ensembl peptide - ENSMUSP00000123898
NCBI entrez gene - 20916     See in Manteia.
MGI - MGI:1306775
RefSeq - XM_006518758
RefSeq - NM_011506
RefSeq - XM_006518757
RefSeq Peptide - NP_035636
swissprot - Q9Z2I9
Ensembl - ENSMUSG00000022110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sucla2ENSDARG00000005359Danio rerio
 SUCLA2ENSGALG00000016993Gallus gallus
 Q9P2R7ENSG00000136143Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z2I8 / Suclg2 / Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial / Q96I99* / succinate-CoA ligase GDP-forming beta subunit*ENSMUSG0000006183847


Protein motifs (from Interpro)
Interpro ID Name
 IPR005809  Succinate--CoA synthetase, beta subunit
 IPR005811  ATP-citrate lyase/succinyl-CoA ligase
 IPR011761  ATP-grasp fold
 IPR013650  ATP-grasp fold, succinyl-CoA synthetase-type
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016102  Succinyl-CoA synthetase-like
 IPR017866  Succinyl-CoA synthetase, beta subunit, conserved site
 IPR034723  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006104 succinyl-CoA metabolic process IEA
 biological_processGO:0006105 succinate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004774 succinate-CoA ligase activity ISS
 molecular_functionGO:0004775 succinate-CoA ligase (ADP-forming) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001711 abnormal placenta 
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptp4a1Gt(CC0606)Wtsi/Ptp4a1+,Ptp4a2Gt(AQ0673)Wtsi/Ptp4a2Gt(AQ0673)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003979 increased circulating carnitine level "greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+
Genetic Background: involves: 129S/SvEv * C57BL/6N

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+
Genetic Background: involves: 129S/SvEv * C57BL/6N

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+
Genetic Background: involves: 129S/SvEv * C57BL/6N

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sucla2Gt(SAbetageo)1Bhg/Sucla2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1(tetO-Cyp26b1)Mfra/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+
Genetic Background: involves: 129S/SvEv * C57BL/6N

Allelic Composition: Sucla2Gt(IST10208H1)Tigm/Sucla2+,Suclg2Gt(Ayu21-KBW131)Imeg/Suclg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052738 Q9WUM5 / Suclg1 / Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial / P53597* / succinate-CoA ligase alpha subunit*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr