ENSG00000174840


Homo sapiens

Features
Gene ID: ENSG00000174840
  
Biological name :PDE12
  
Synonyms : PDE12 / phosphodiesterase 12 / Q6L8Q7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p14.3
Gene start: 57556276
Gene end: 57566844
  
Corresponding Affymetrix probe sets: 1554915_a_at (Human Genome U133 Plus 2.0 Array)   214826_at (Human Genome U133 Plus 2.0 Array)   231839_at (Human Genome U133 Plus 2.0 Array)   235091_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309142
Ensembl peptide - ENSP00000420626
NCBI entrez gene - 201626     See in Manteia.
OMIM - 616519
RefSeq - NM_001322177
RefSeq - NM_177966
RefSeq Peptide - NP_001309106
RefSeq Peptide - NP_808881
swissprot - Q6L8Q7
swissprot - F6T1Q0
Ensembl - ENSG00000174840
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde12ENSDARG00000030964Danio rerio
 PDE12ENSGALG00000005620Gallus gallus
 Pde12ENSMUSG00000043702Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANGEL1 / Q9UNK9 / angel homolog 1ENSG0000001352319
CNOT6 / Q9ULM6 / CCR4-NOT transcription complex subunit 6ENSG0000011330019
CNOT6L / Q96LI5 / CCR4-NOT transcription complex subunit 6 likeENSG0000013876719
ANGEL2 / Q5VTE6 / angel homolog 2ENSG0000017460618
NOCT / Q9UK39 / nocturninENSG0000015101417


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 biological_processGO:0000958 mitochondrial mRNA catabolic process IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0035457 cellular response to interferon-alpha IMP
 biological_processGO:0044528 regulation of mitochondrial mRNA stability IMP
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071359 cellular response to dsRNA IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IDA
 biological_processGO:0090324 negative regulation of oxidative phosphorylation IMP
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IMP
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IMP
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IMP
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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