ENSG00000138767


Homo sapiens

Features
Gene ID: ENSG00000138767
  
Biological name :CNOT6L
  
Synonyms : CCR4-NOT transcription complex subunit 6 like / CNOT6L / Q96LI5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.1
Gene start: 77713387
Gene end: 77819615
  
Corresponding Affymetrix probe sets: 1553266_at (Human Genome U133 Plus 2.0 Array)   1553267_a_at (Human Genome U133 Plus 2.0 Array)   226153_s_at (Human Genome U133 Plus 2.0 Array)   227119_at (Human Genome U133 Plus 2.0 Array)   238438_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423750
Ensembl peptide - ENSP00000425836
Ensembl peptide - ENSP00000426320
Ensembl peptide - ENSP00000426269
Ensembl peptide - ENSP00000424896
Ensembl peptide - ENSP00000425571
NCBI entrez gene - 246175     See in Manteia.
RefSeq - XM_017007957
RefSeq - NM_001286790
RefSeq - NM_144571
RefSeq - XM_011531806
RefSeq - XM_011531807
RefSeq - XM_011531808
RefSeq - XM_011531809
RefSeq - XM_011531810
RefSeq - XM_017007956
RefSeq Peptide - NP_001273719
RefSeq Peptide - NP_653172
swissprot - H0Y9Z5
swissprot - H0YA76
swissprot - D6RIW9
swissprot - D6RGK9
swissprot - Q96LI5
swissprot - H0Y9C1
Ensembl - ENSG00000138767
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2BHJ4ENSDARG00000054597Danio rerio
 CNOT6LENSGALG00000010333Gallus gallus
 Cnot6lENSMUSG00000034724Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNOT6 / Q9ULM6 / CCR4-NOT transcription complex subunit 6ENSG0000011330079
ANGEL1 / Q9UNK9 / angel homolog 1ENSG0000001352322
PDE12 / Q6L8Q7 / phosphodiesterase 12ENSG0000017484021
ANGEL2 / Q5VTE6 / angel homolog 2ENSG0000017460619
NOCT / Q9UK39 / nocturninENSG0000015101419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034967  CCR4-NOT transcription complex subunit 6-like
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0061157 mRNA destabilization IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr