ENSMUSG00000043702


Mus musculus

Features
Gene ID: ENSMUSG00000043702
  
Biological name :Pde12
  
Synonyms : 2,5-phosphodiesterase 12 / Pde12 / Q3TIU4
  
Possible biological names infered from orthology : phosphodiesterase 12 / Q6L8Q7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 26659958
Gene end: 26669883
  
Corresponding Affymetrix probe sets: 10418247 (MoGene1.0st)   1440338_at (Mouse Genome 430 2.0 Array)   1443869_at (Mouse Genome 430 2.0 Array)   1454963_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059666
NCBI entrez gene - 211948     See in Manteia.
MGI - MGI:2443226
RefSeq - NM_178668
RefSeq Peptide - NP_848783
swissprot - Q3TIU4
Ensembl - ENSMUSG00000043702
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde12ENSDARG00000030964Danio rerio
 PDE12ENSGALG00000005620Gallus gallus
 PDE12ENSG00000174840Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnot6l / Q8VEG6 / CCR4-NOT transcription complex subunit 6-like / Q96LI5*ENSMUSG0000003472419
1 / Angel1 / Q8VCU0 / Q9UNK9* / angel homolog 1*ENSMUSG0000002125719
Cnot6 / Q8K3P5 / CCR4-NOT transcription complex subunit 6 / Q9ULM6*ENSMUSG0000002036219
Noct / O35710 / Nocturnin / Q9UK39*ENSMUSG0000002308717
Angel2 / Q8K1C0 / Mus musculus angel homolog 2 (Angel2), transcript variant 3, mRNA. / Q5VTE6* / angel homolog 2*ENSMUSG0000002663417


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
 biological_processGO:0000958 mitochondrial mRNA catabolic process IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0044528 regulation of mitochondrial mRNA stability IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090324 negative regulation of oxidative phosphorylation IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity ISO
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010580 decreased heart left ventricle size "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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