ENSMUSG00000023087


Mus musculus

Features
Gene ID: ENSMUSG00000023087
  
Biological name :Noct
  
Synonyms : Noct / Nocturnin / O35710
  
Possible biological names infered from orthology : Q9UK39
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 51224447
Gene end: 51251644
  
Corresponding Affymetrix probe sets: 10491915 (MoGene1.0st)   1425837_a_at (Mouse Genome 430 2.0 Array)   1448715_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130347
Ensembl peptide - ENSMUSP00000142216
Ensembl peptide - ENSMUSP00000141416
Ensembl peptide - ENSMUSP00000023849
NCBI entrez gene - 12457     See in Manteia.
MGI - MGI:109382
RefSeq - NM_009834
RefSeq - XM_006500956
RefSeq Peptide - NP_033964
swissprot - B2RTJ8
swissprot - O35710
swissprot - A0A0A6YY01
Ensembl - ENSMUSG00000023087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noctaENSDARG00000077726Danio rerio
 noctbENSDARG00000078525Danio rerio
 NOCTENSGALG00000032957Gallus gallus
 NOCTENSG00000151014Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
1 / Angel1 / Q8VCU0 / Q9UNK9* / angel homolog 1*ENSMUSG0000002125726
Angel2 / Q8K1C0 / Mus musculus angel homolog 2 (Angel2), transcript variant 3, mRNA. / Q5VTE6* / angel homolog 2*ENSMUSG0000002663425
Pde12 / Q3TIU4 / 2,5-phosphodiesterase 12 / Q6L8Q7* / phosphodiesterase 12*ENSMUSG0000004370224
Cnot6l / Q8VEG6 / CCR4-NOT transcription complex subunit 6-like / Q96LI5*ENSMUSG0000003472424
Cnot6 / Q8K3P5 / CCR4-NOT transcription complex subunit 6 / Q9ULM6*ENSMUSG0000002036223


Protein motifs (from Interpro)
Interpro ID Name
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR034965  Nocturnin, deadenylase domain
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0009991 response to extracellular stimulus IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IGI
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045995 regulation of embryonic development IMP
 biological_processGO:0048255 mRNA stabilization IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Arntltm1Bra/Arntltm1Bra,Tg(Scg2-tTA)1Jt/0,Tg(tetO-Arntl)1Jt/0
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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