ENSMUSG00000020362


Mus musculus

Features
Gene ID: ENSMUSG00000020362
  
Biological name :Cnot6
  
Synonyms : CCR4-NOT transcription complex subunit 6 / Cnot6 / Q8K3P5
  
Possible biological names infered from orthology : Q9ULM6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.2
Gene start: 49671503
Gene end: 49712723
  
Corresponding Affymetrix probe sets: 10385557 (MoGene1.0st)   1426682_at (Mouse Genome 430 2.0 Array)   1426683_at (Mouse Genome 430 2.0 Array)   1426684_at (Mouse Genome 430 2.0 Array)   1426685_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020624
Ensembl peptide - ENSMUSP00000121239
NCBI entrez gene - 104625     See in Manteia.
MGI - MGI:2144529
RefSeq - XM_017314215
RefSeq - NM_001290741
RefSeq - NM_212484
RefSeq - XM_006531942
RefSeq - XM_011248665
RefSeq - XM_017314214
RefSeq - XM_006531940
RefSeq - XM_006531941
RefSeq Peptide - NP_997649
RefSeq Peptide - NP_001277670
swissprot - Q8K3P5
Ensembl - ENSMUSG00000020362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot6aENSDARG00000008255Danio rerio
 cnot6bENSDARG00000101072Danio rerio
 CNOT6ENSGALG00000034316Gallus gallus
 CNOT6ENSG00000113300Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnot6l / Q8VEG6 / CCR4-NOT transcription complex subunit 6-like / Q96LI5*ENSMUSG0000003472476
Angel2 / Q8K1C0 / Mus musculus angel homolog 2 (Angel2), transcript variant 3, mRNA. / Q5VTE6* / angel homolog 2*ENSMUSG0000002663421
1 / Angel1 / Q8VCU0 / Q9UNK9* / angel homolog 1*ENSMUSG0000002125721
Pde12 / Q3TIU4 / 2,5-phosphodiesterase 12 / Q6L8Q7* / phosphodiesterase 12*ENSMUSG0000004370220
Noct / O35710 / Nocturnin / Q9UK39*ENSMUSG0000002308717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034966  CCR4-NOT transcription complex subunit 6
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly ISO
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay ISO
 biological_processGO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay ISO
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:2000327 positive regulation of nuclear receptor transcription coactivator activity ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030014 CCR4-NOT complex ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004532 exoribonuclease activity ISS
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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