ENSG00000176890


Homo sapiens

Features
Gene ID: ENSG00000176890
  
Biological name :TYMS
  
Synonyms : P04818 / thymidylate synthetase / TYMS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.32
Gene start: 657604
Gene end: 673578
  
Corresponding Affymetrix probe sets: 1554696_s_at (Human Genome U133 Plus 2.0 Array)   202589_at (Human Genome U133 Plus 2.0 Array)   217684_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000315644
Ensembl peptide - ENSP00000314727
Ensembl peptide - ENSP00000314902
NCBI entrez gene - 7298     See in Manteia.
OMIM - 188350
RefSeq - NM_001071
RefSeq Peptide - NP_001062
swissprot - P04818
swissprot - Q53Y97
Ensembl - ENSG00000176890
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tymsENSDARG00000042894Danio rerio
 TYMSENSGALG00000014897Gallus gallus
 TymsENSMUSG00000025747Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000398  Thymidylate synthase
 IPR020940  Thymidylate synthase, active site
 IPR023451  Thymidylate synthase/dCMP hydroxymethylase domain
 IPR036926  Thymidylate synthase/dCMP hydroxymethylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006206 pyrimidine nucleobase metabolic process IEA
 biological_processGO:0006231 dTMP biosynthetic process IDA
 biological_processGO:0006235 dTTP biosynthetic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0019088 immortalization of host cell by virus IEA
 biological_processGO:0019860 uracil metabolic process IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046078 dUMP metabolic process IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0046683 response to organophosphorus IEP
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0071897 DNA biosynthetic process IC
 biological_processGO:0097421 liver regeneration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IDA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004799 thymidylate synthase activity TAS
 molecular_functionGO:0005542 folic acid binding IC
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048037 cofactor binding IEA
 molecular_functionGO:1990825 sequence-specific mRNA binding IDA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates
Activation of E2F1 target genes at G1/S


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000176890 TYMS / P04818 / thymidylate synthetase  / complex






 

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