ENSMUSG00000025747


Mus musculus

Features
Gene ID: ENSMUSG00000025747
  
Biological name :Tyms
  
Synonyms : P07607 / thymidylate synthase / Tyms
  
Possible biological names infered from orthology : P04818 / thymidylate synthetase
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 30058202
Gene end: 30073617
  
Corresponding Affymetrix probe sets: 10528915 (MoGene1.0st)   1424991_s_at (Mouse Genome 430 2.0 Array)   1427810_at (Mouse Genome 430 2.0 Array)   1427811_at (Mouse Genome 430 2.0 Array)   1438690_at (Mouse Genome 430 2.0 Array)   1442192_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026846
Ensembl peptide - ENSMUSP00000143552
Ensembl peptide - ENSMUSP00000143540
Ensembl peptide - ENSMUSP00000143001
Ensembl peptide - ENSMUSP00000142970
Ensembl peptide - ENSMUSP00000123377
NCBI entrez gene - 22171     See in Manteia.
MGI - MGI:98878
RefSeq - XM_017320801
RefSeq - NM_021288
RefSeq - XM_011249762
RefSeq Peptide - NP_067263
swissprot - A0A0G2JGG2
swissprot - D6RCW9
swissprot - P07607
swissprot - Q544L2
swissprot - A0A0G2JGF0
swissprot - A0A0G2JF03
swissprot - A0A0G2JF31
Ensembl - ENSMUSG00000025747
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tymsENSDARG00000042894Danio rerio
 TYMSENSGALG00000014897Gallus gallus
 TYMSENSG00000176890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000398  Thymidylate synthase
 IPR020940  Thymidylate synthase, active site
 IPR023451  Thymidylate synthase/dCMP hydroxymethylase domain
 IPR036926  Thymidylate synthase/dCMP hydroxymethylase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006206 pyrimidine nucleobase metabolic process IEA
 biological_processGO:0006231 dTMP biosynthetic process IEA
 biological_processGO:0006235 dTTP biosynthetic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0019088 immortalization of host cell by virus IEA
 biological_processGO:0019860 uracil metabolic process IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035999 tetrahydrofolate interconversion IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046078 dUMP metabolic process IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process IEA
 biological_processGO:0046683 response to organophosphorus IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0097421 liver regeneration IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004799 thymidylate synthase activity IEA
 molecular_functionGO:0005542 folic acid binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048037 cofactor binding IEA
 molecular_functionGO:1990825 sequence-specific mRNA binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025747 Tyms / P07607 / thymidylate synthase / P04818* / thymidylate synthetase*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr