ENSG00000178700


Homo sapiens

Features
Gene ID: ENSG00000178700
  
Biological name :DHFR2
  
Synonyms : DHFR2 / dihydrofolate reductase 2 / Q86XF0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q11.2
Gene start: 94047836
Gene end: 94063389
  
Corresponding Affymetrix probe sets: 235675_at (Human Genome U133 Plus 2.0 Array)   241727_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418415
Ensembl peptide - ENSP00000480823
Ensembl peptide - ENSP00000420810
Ensembl peptide - ENSP00000319170
Ensembl peptide - ENSP00000377768
NCBI entrez gene - 200895     See in Manteia.
OMIM - 616588
RefSeq - XM_011512537
RefSeq - NM_001195643
RefSeq - NM_176815
RefSeq Peptide - NP_001182572
RefSeq Peptide - NP_789785
swissprot - Q86XF0
swissprot - C9JJ68
Ensembl - ENSG00000178700
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhfrENSDARG00000004251Danio rerio
 DHFRENSGALG00000026757Gallus gallus
 DhfrENSMUSG00000021707Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHFR / P00374 / dihydrofolate reductaseENSG0000022871692


Protein motifs (from Interpro)
Interpro ID Name
 IPR001796  Dihydrofolate reductase domain
 IPR012259  Dihydrofolate reductase
 IPR024072  Dihydrofolate reductase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006545 glycine biosynthetic process IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0046105 thymidine biosynthetic process IDA
 biological_processGO:0046653 tetrahydrofolate metabolic process IDA
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IMP
 cellular_componentGO:0005759 mitochondrial matrix IMP
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004146 dihydrofolate reductase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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