ENSMUSG00000021707


Mus musculus

Features
Gene ID: ENSMUSG00000021707
  
Biological name :Dhfr
  
Synonyms : Dhfr / Dihydrofolate reductase / P00375
  
Possible biological names infered from orthology : DHFR2 / dihydrofolate reductase 2 / P00374 / Q86XF0
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 92354726
Gene end: 92389053
  
Corresponding Affymetrix probe sets: 10406581 (MoGene1.0st)   1419172_at (Mouse Genome 430 2.0 Array)   1430750_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022218
NCBI entrez gene - 13361     See in Manteia.
MGI - MGI:94890
RefSeq - NM_010049
RefSeq Peptide - NP_034179
swissprot - P00375
swissprot - Q544T5
Ensembl - ENSMUSG00000021707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhfrENSDARG00000004251Danio rerio
 DHFRENSGALG00000026757Gallus gallus
 DHFRENSG00000228716Homo sapiens
 DHFR2ENSG00000178700Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001796  Dihydrofolate reductase domain
 IPR012259  Dihydrofolate reductase
 IPR017925  Dihydrofolate reductase conserved site
 IPR024072  Dihydrofolate reductase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006545 glycine biosynthetic process IEA
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process IMP
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031427 response to methotrexate IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0046452 dihydrofolate metabolic process IEA
 biological_processGO:0046653 tetrahydrofolate metabolic process ISO
 biological_processGO:0046654 tetrahydrofolate biosynthetic process ISO
 biological_processGO:0046655 folic acid metabolic process IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IMP
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:2000121 regulation of removal of superoxide radicals IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0004146 dihydrofolate reductase activity TAS
 molecular_functionGO:0005542 folic acid binding ISO
 molecular_functionGO:0008144 drug binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0051870 methotrexate binding ISO
 molecular_functionGO:0051871 dihydrofolic acid binding IEA
 molecular_functionGO:0070402 NADPH binding ISO
 molecular_functionGO:1990825 sequence-specific mRNA binding ISO


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0011111 complete lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011230 abnormal folic acid level "any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia" [MESH:D03.438.733.631.400]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Dhfrorana/Dhfr+
Genetic Background: involves: C57BL/6JAnu

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0013693 abnormal hemopoiesis "any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]
Show

Allelic Composition: Dhfrorana/Dhfr+
Genetic Background: involves: C57BL/6JAnu

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Dhfrorana/Dhfr+
Genetic Background: involves: C57BL/6JAnu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021707 Dhfr / P00375 / Dihydrofolate reductase / DHFR2* / P00374* / Q86XF0* / dihydrofolate reductase 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr