ENSG00000181019


Homo sapiens

Features
Gene ID: ENSG00000181019
  
Biological name :NQO1
  
Synonyms : NAD(P)H quinone dehydrogenase 1 / NQO1 / P15559
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 69706996
Gene end: 69726951
  
Corresponding Affymetrix probe sets: 201467_s_at (Human Genome U133 Plus 2.0 Array)   201468_s_at (Human Genome U133 Plus 2.0 Array)   210519_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000455020
Ensembl peptide - ENSP00000398330
Ensembl peptide - ENSP00000456282
Ensembl peptide - ENSP00000319788
Ensembl peptide - ENSP00000368334
Ensembl peptide - ENSP00000368335
NCBI entrez gene - 1728     See in Manteia.
OMIM - 125860
RefSeq - NM_000903
RefSeq - NM_001025434
RefSeq - NM_001286137
RefSeq - NM_001025433
RefSeq Peptide - NP_000894
RefSeq Peptide - NP_001020605
RefSeq Peptide - NP_001273066
RefSeq Peptide - NP_001020604
swissprot - P15559
swissprot - B4DLR8
swissprot - H3BNV2
swissprot - H3BRK3
Ensembl - ENSG00000181019
  
Related genetic diseases (OMIM): 125860 - {Benzene toxicity, susceptibility to}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nqo1ENSDARG00000010250Danio rerio
 NQO1ENSGALG00000023437Gallus gallus
 Nqo1ENSMUSG00000003849Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NQO2 / P16083 / N-ribosyldihydronicotinamide:quinone reductase 2ENSG0000012458839


Protein motifs (from Interpro)
Interpro ID Name
 IPR003680  Flavodoxin-like fold
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0006809 nitric oxide biosynthetic process TAS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007271 synaptic transmission, cholinergic TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009636 response to toxic substance TAS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:1901698 response to nitrogen compound IEA
 biological_processGO:1904880 response to hydrogen sulfide IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003955 NAD(P)H dehydrogenase (quinone) activity TAS
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS
 molecular_functionGO:0004784 superoxide dismutase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of ornithine decarboxylase (ODC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115758 ODC1 / P11926 / ornithine decarboxylase 1  / complex / reaction






 

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