ENSG00000115758


Homo sapiens

Features
Gene ID: ENSG00000115758
  
Biological name :ODC1
  
Synonyms : ODC1 / ornithine decarboxylase 1 / P11926
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p25.1
Gene start: 10439968
Gene end: 10448504
  
Corresponding Affymetrix probe sets: 200790_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390691
Ensembl peptide - ENSP00000234111
Ensembl peptide - ENSP00000385333
NCBI entrez gene - 4953     See in Manteia.
OMIM - 165640
RefSeq - NM_001287189
RefSeq - NM_001287188
RefSeq - NM_001287190
RefSeq - NM_002539
RefSeq Peptide - NP_001274117
RefSeq Peptide - NP_001274118
RefSeq Peptide - NP_001274119
RefSeq Peptide - NP_002530
swissprot - P11926
swissprot - C9JG30
Ensembl - ENSG00000115758
  
Related genetic diseases (OMIM): 114500 - {Colonic adenoma recurrence, reduced risk of}, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 odc1ENSDARG00000007377Danio rerio
 ODC1ENSGALG00000016444Gallus gallus
 Odc1ENSMUSG00000011179Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AZIN2 / Q96A70 / antizyme inhibitor 2ENSG0000014292051
AZIN1 / O14977 / antizyme inhibitor 1ENSG0000015509649


Protein motifs (from Interpro)
Interpro ID Name
 IPR000183  Ornithine/DAP/Arg decarboxylase
 IPR002433  Ornithine decarboxylase
 IPR009006  Alanine racemase/group IV decarboxylase, C-terminal
 IPR022643  Orn/DAP/Arg decarboxylase 2, C-terminal
 IPR022644  Orn/DAP/Arg decarboxylase 2, N-terminal
 IPR022653  Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
 IPR022657  Orn/DAP/Arg decarboxylase 2, conserved site
 IPR029066  PLP-binding barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0006595 polyamine metabolic process TAS
 biological_processGO:0006596 polyamine biosynthetic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009446 putrescine biosynthetic process IEA
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0033387 putrescine biosynthetic process from ornithine ISS
 biological_processGO:0042176 regulation of protein catabolic process ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004586 ornithine decarboxylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Regulation of ornithine decarboxylase (ODC)
Metabolism of polyamines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000180304 OAZ2 / O95190 / ornithine decarboxylase antizyme 2  / reaction / complex
 ENSG00000143450 OAZ3 / Q9UMX2 / ornithine decarboxylase antizyme 3  / reaction / complex
 ENSG00000104904 OAZ1 / P54368 / ornithine decarboxylase antizyme 1  / complex / reaction
 ENSG00000155096 AZIN1 / O14977 / antizyme inhibitor 1  / reaction / complex
 ENSG00000181019 NQO1 / P15559 / NAD(P)H quinone dehydrogenase 1  / reaction / complex






 

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