ENSMUSG00000011179


Mus musculus

Features
Gene ID: ENSMUSG00000011179
  
Biological name :Odc1
  
Synonyms : Odc1 / ornithine decarboxylase, structural 1 / P00860
  
Possible biological names infered from orthology : ornithine decarboxylase 1 / P11926
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 17544794
Gene end: 17551505
  
Corresponding Affymetrix probe sets: 10394770 (MoGene1.0st)   10582295 (MoGene1.0st)   1427364_a_at (Mouse Genome 430 2.0 Array)   1437711_x_at (Mouse Genome 430 2.0 Array)   1438761_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128661
Ensembl peptide - ENSMUSP00000152699
Ensembl peptide - ENSMUSP00000152363
NCBI entrez gene - 18263     See in Manteia.
MGI - MGI:97402
RefSeq - NM_013614
RefSeq - XM_017314990
RefSeq Peptide - NP_038642
swissprot - A0A1Y7VMF9
swissprot - P00860
swissprot - A0A1Y7VJC5
Ensembl - ENSMUSG00000011179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 odc1ENSDARG00000007377Danio rerio
 ODC1ENSGALG00000016444Gallus gallus
 ODC1ENSG00000115758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Azin1 / O35484 / Antizyme inhibitor 1 / O14977*ENSMUSG0000003745849
Azin2 / Q8BVM4 / Antizyme inhibitor 2 / Q96A70*ENSMUSG0000002878948
Gm853ENSMUSG0000002312042


Protein motifs (from Interpro)
Interpro ID Name
 IPR000183  Ornithine/DAP/Arg decarboxylase
 IPR002433  Ornithine decarboxylase
 IPR009006  Alanine racemase/group IV decarboxylase, C-terminal
 IPR022643  Orn/DAP/Arg decarboxylase 2, C-terminal
 IPR022644  Orn/DAP/Arg decarboxylase 2, N-terminal
 IPR022653  Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
 IPR022657  Orn/DAP/Arg decarboxylase 2, conserved site
 IPR029066  PLP-binding barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006595 polyamine metabolic process IEA
 biological_processGO:0006596 polyamine biosynthetic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009446 putrescine biosynthetic process IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0033387 putrescine biosynthetic process from ornithine IEA
 biological_processGO:0042176 regulation of protein catabolic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004586 ornithine decarboxylase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Regulation of ornithine decarboxylase (ODC)
Metabolism of polyamines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Gtpbp2tm1b(KOMP)Mbp/Gtpbp2+
Genetic Background: C57BL/6N-Gtpbp2tm1b(KOMP)Mbp/Ucd

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003849 Nqo1 / Q64669 / NAD(P)H dehydrogenase [quinone] 1 / P15559* / NAD(P)H quinone dehydrogenase 1*  / complex / reaction
 ENSMUSG00000035242 Oaz1 / P54369 / Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 1, mRNA. / P54368* / ornithine decarboxylase antizyme 1*  / reaction / complex
 ENSMUSG00000037458 Azin1 / O35484 / Antizyme inhibitor 1 / O14977*  / complex / reaction
 ENSMUSG00000040652 Oaz2 / O08608 / Mus musculus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 1, mRNA. / O95190* / ornithine decarboxylase antizyme 2*  / reaction / complex
 ENSMUSG00000028141 Oaz3 / Q9R109 / Mus musculus ornithine decarboxylase antizyme 3 (Oaz3), mRNA. / Q9UMX2* / ornithine decarboxylase antizyme 3*  / complex / reaction






 

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