ENSMUSG00000003849


Mus musculus

Features
Gene ID: ENSMUSG00000003849
  
Biological name :Nqo1
  
Synonyms : NAD(P)H dehydrogenase [quinone] 1 / Nqo1 / Q64669
  
Possible biological names infered from orthology : NAD(P)H quinone dehydrogenase 1 / P15559
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 107388225
Gene end: 107403206
  
Corresponding Affymetrix probe sets: 10581538 (MoGene1.0st)   1423627_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003947
NCBI entrez gene - 18104     See in Manteia.
MGI - MGI:103187
RefSeq - NM_008706
RefSeq Peptide - NP_032732
swissprot - Q542Y0
swissprot - Q64669
Ensembl - ENSMUSG00000003849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nqo1ENSDARG00000010250Danio rerio
 NQO1ENSGALG00000023437Gallus gallus
 NQO1ENSG00000181019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nqo2 / Q9JI75 / N-ribosyldihydronicotinamide quinone reductase 2 / P16083*ENSMUSG0000004694941


Protein motifs (from Interpro)
Interpro ID Name
 IPR003680  Flavodoxin-like fold
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:1901698 response to nitrogen compound IEA
 biological_processGO:1904880 response to hydrogen sulfide IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003955 NAD(P)H dehydrogenase (quinone) activity IDA
 molecular_functionGO:0004784 superoxide dismutase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of ornithine decarboxylase (ODC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000011179 Odc1 / P00860 / ornithine decarboxylase, structural 1 / P11926* / ornithine decarboxylase 1*  / complex / reaction






 

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