ENSMUSG00000046949


Mus musculus

Features
Gene ID: ENSMUSG00000046949
  
Biological name :Nqo2
  
Synonyms : Nqo2 / N-ribosyldihydronicotinamide quinone reductase 2 / Q9JI75
  
Possible biological names infered from orthology : P16083
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.3
Gene start: 33964687
Gene end: 33988443
  
Corresponding Affymetrix probe sets: 10404496 (MoGene1.0st)   1436189_at (Mouse Genome 430 2.0 Array)   1449983_a_at (Mouse Genome 430 2.0 Array)   1455590_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021843
Ensembl peptide - ENSMUSP00000152068
Ensembl peptide - ENSMUSP00000152294
Ensembl peptide - ENSMUSP00000152598
Ensembl peptide - ENSMUSP00000053809
NCBI entrez gene - 18105     See in Manteia.
MGI - MGI:104513
RefSeq - XM_006516575
RefSeq - NM_001163239
RefSeq - NM_001163241
RefSeq - NM_001163242
RefSeq - NM_020282
RefSeq - XM_006516574
RefSeq Peptide - NP_001156714
RefSeq Peptide - NP_001156713
RefSeq Peptide - NP_001156711
RefSeq Peptide - NP_064678
swissprot - A0A1Y7VL95
swissprot - A0A1Y7VMA0
swissprot - Q9JI75
Ensembl - ENSMUSG00000046949
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NQO2ENSGALG00000025747Gallus gallus
 NQO2ENSG00000124588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nqo1 / Q64669 / NAD(P)H dehydrogenase [quinone] 1 / P15559* / NAD(P)H quinone dehydrogenase 1*ENSMUSG0000000384948


Protein motifs (from Interpro)
Interpro ID Name
 IPR003680  Flavodoxin-like fold
 IPR029039  Flavoprotein-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007613 memory IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0001512 dihydronicotinamide riboside quinone reductase activity ISO
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0009055 electron transfer activity ISO
 molecular_functionGO:0016491 oxidoreductase activity ISO
 molecular_functionGO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
 molecular_functionGO:0031404 chloride ion binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071949 FAD binding ISO
 molecular_functionGO:1904408 melatonin binding ISO
 molecular_functionGO:1905594 resveratrol binding ISO


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtpbp1pcd-6J/Agtpbp1pcd-6J
Genetic Background: C57BL/6J-Agtpbp1pcd-6J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046949 Nqo2 / Q9JI75 / N-ribosyldihydronicotinamide quinone reductase 2 / P16083*  / complex






 

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