ENSMUSG00000028141


Mus musculus

Features
Gene ID: ENSMUSG00000028141
  
Biological name :Oaz3
  
Synonyms : Mus musculus ornithine decarboxylase antizyme 3 (Oaz3), mRNA. / Oaz3 / Q9R109
  
Possible biological names infered from orthology : ornithine decarboxylase antizyme 3 / Q9UMX2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 94432414
Gene end: 94443915
  
Corresponding Affymetrix probe sets: 10499981 (MoGene1.0st)   1429341_at (Mouse Genome 430 2.0 Array)   1437010_a_at (Mouse Genome 430 2.0 Array)   1437011_x_at (Mouse Genome 430 2.0 Array)   1453115_at (Mouse Genome 430 2.0 Array)   1454279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139408
Ensembl peptide - ENSMUSP00000145484
Ensembl peptide - ENSMUSP00000145113
Ensembl peptide - ENSMUSP00000145079
Ensembl peptide - ENSMUSP00000144790
Ensembl peptide - ENSMUSP00000143080
NCBI entrez gene - 53814     See in Manteia.
MGI - MGI:1858170
RefSeq - NM_016901
swissprot - A0A0N4SVF4
swissprot - A0A0N4SUR5
swissprot - A0A0G2JF96
swissprot - A0A0N4SWE3
swissprot - Q9R109
swissprot - A0A0N4SVI0
Ensembl - ENSMUSG00000028141
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oaz2bENSDARG00000059815Danio rerio
 OAZ3ENSG00000143450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oaz1 / P54369 / Mus musculus ornithine decarboxylase antizyme 1 (Oaz1), transcript variant 1, mRNA. / P54368* / ornithine decarboxylase antizyme 1*ENSMUSG0000003524225
Oaz2 / O08608 / Mus musculus ornithine decarboxylase antizyme 2 (Oaz2), transcript variant 1, mRNA. / O95190* / ornithine decarboxylase antizyme 2*ENSMUSG0000004065224


Protein motifs (from Interpro)
Interpro ID Name
 IPR002993  Ornithine decarboxylase antizyme
 IPR016181  Acyl-CoA N-acyltransferase
 IPR029913  Ornithine decarboxylase antizyme 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006595 polyamine metabolic process TAS
 biological_processGO:0006596 polyamine biosynthetic process IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0015847 putrescine transport IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0090316 positive regulation of intracellular protein transport IDA
 biological_processGO:1902268 negative regulation of polyamine transmembrane transport IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008073 ornithine decarboxylase inhibitor activity ISO
 molecular_functionGO:0015489 putrescine transmembrane transporter activity IDA


Pathways (from Reactome)
Pathway description
Regulation of ornithine decarboxylase (ODC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037458 Azin1 / O35484 / Antizyme inhibitor 1 / O14977*  / reaction / complex
 ENSMUSG00000011179 Odc1 / P00860 / ornithine decarboxylase, structural 1 / P11926* / ornithine decarboxylase 1*  / complex / reaction






 

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